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PXD046708

PXD046708 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSART3 is a Novel Rme2s Reader studied by tandem MS
DescriptionArginine methylation is a ubiquitous post-translational modification involved in many biological processes such as transcription, cell signaling and RNA splicing. Tudor domains by far are the major effector domain family for arginine methylation mark recognition. Here we characterize SART3 as a novel selective reader for symmetric dimethylarginine (Rme2s) marks. SART3 harbors a series of HAT (Half-a-TPR) repeats that are aromatic-rich, and it is this region that binds Rme2s motifs. An analysis of the reported structure of the HAT repeats of SART3 identified a putative aromatic cage that potentially “read” the Rme2s-modified motifs, and the key aromatic residues required for Rme2s recognition were identified. We further confirm that this Rme2s reader ability is important for SART3-mediated RNA splicing. Together, our studies revealed that the evolutionarily conserved SART3 HAT domain was a novel reader of Rme2s mark involved in RNA splicing.
HostingRepositoryPRIDE
AnnounceDate2024-10-17
AnnouncementXMLSubmission_2024-10-17_02:38:53.882.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD046708
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterWilliam Russell
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonomethylated residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-11-06 13:07:33ID requested
12024-10-17 02:38:54announced
Publication List
10.6019/PXD046708;
10.1016/j.celrep.2024.114459;
Wang Y, Zhou J, He W, Fu R, Shi L, Dang NK, Liu B, Xu H, Cheng X, Bedford MT, SART3 reads methylarginine-marked glycine- and arginine-rich motifs. Cell Rep, 43(7):114459(2024) [pubmed]
Keyword List
submitter keyword: apms, lcms,Arginine methylation
Contact List
Mark Bedford
contact affiliationUT-MDACC
contact emailmtbedford@mdanderson.org
lab head
William Russell
contact affiliationUT-Medical Branch
contact emailbill.russell@utmb.edu
dataset submitter
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Dataset FTP location
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PRIDE project URI
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