PXD046708 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | SART3 is a Novel Rme2s Reader studied by tandem MS |
Description | Arginine methylation is a ubiquitous post-translational modification involved in many biological processes such as transcription, cell signaling and RNA splicing. Tudor domains by far are the major effector domain family for arginine methylation mark recognition. Here we characterize SART3 as a novel selective reader for symmetric dimethylarginine (Rme2s) marks. SART3 harbors a series of HAT (Half-a-TPR) repeats that are aromatic-rich, and it is this region that binds Rme2s motifs. An analysis of the reported structure of the HAT repeats of SART3 identified a putative aromatic cage that potentially “read” the Rme2s-modified motifs, and the key aromatic residues required for Rme2s recognition were identified. We further confirm that this Rme2s reader ability is important for SART3-mediated RNA splicing. Together, our studies revealed that the evolutionarily conserved SART3 HAT domain was a novel reader of Rme2s mark involved in RNA splicing. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-17 |
AnnouncementXML | Submission_2024-10-17_02:38:53.882.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD046708 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | William Russell |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monomethylated residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-11-06 13:07:33 | ID requested | |
⏵ 1 | 2024-10-17 02:38:54 | announced | |
Publication List
10.6019/PXD046708; |
10.1016/j.celrep.2024.114459; |
Wang Y, Zhou J, He W, Fu R, Shi L, Dang NK, Liu B, Xu H, Cheng X, Bedford MT, SART3 reads methylarginine-marked glycine- and arginine-rich motifs. Cell Rep, 43(7):114459(2024) [pubmed] |
Keyword List
submitter keyword: apms, lcms,Arginine methylation |
Contact List
Mark Bedford |
contact affiliation | UT-MDACC |
contact email | mtbedford@mdanderson.org |
lab head | |
William Russell |
contact affiliation | UT-Medical Branch |
contact email | bill.russell@utmb.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046708
- Label: PRIDE project
- Name: SART3 is a Novel Rme2s Reader studied by tandem MS