PXD046654

PXD046654 is an original dataset announced via ProteomeXchange.

Title	Sustainability of specific improvements of cardiorespiratory fitness and insulin sensitive metabolism in type 2 diabetes after exercise training
Description	High intensity interval training (HIIT) improves metabolism, but maybe with differences in sustainability between prediabetes and type 2 diabetes (T2D). We hypothesized that HIIT-induced changes are maintained after 4-week detraining in humans with (20 T2D) and without T2D (12 insulin-sensitive, IS-NDM; 10 insulin-resistant, IR-NDM). To explore the change in protein cargo of small extracellular vesicles (SEV), we measured the proteome of SEVs from serum of T2D, IR-NMD and IR-NDM individuals.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_11:57:08.694.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Polina Lipaeva
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-03 10:15:38	ID requested
⏵ 1	2025-05-06 11:57:09	announced

10.1016/j.ebiom.2024.105471;

Mastrototaro L, Apostolopoulou M, Hartwig S, Strassburger K, Lipaeva P, Trinks N, Karusheva Y, Gancheva S, Trenkamp S, Lehr S, Al-Hasani H, Szendroedi J, Roden M, The role of exosomes for sustained specific cardiorespiratory and metabolic improvements in males with type 2 diabetes after detraining. EBioMedicine, 110():105471(2024) [pubmed]

submitter keyword: Exercise

Detraining

Insulin sensitivity

Mitochondrial function

Small extracellular vesicles

Inter-organ crosstalk

Stefan Lehr
contact affiliation	German Center for Diabetes Research, Partner Düsseldorf, München-Neuherberg, Germany
contact email	Stefan.Lehr@ddz.de
lab head
Polina Lipaeva
contact affiliation	Department of Endocrinology and Diabetology, Medical Faculty and University Hospital, Heinrich-Heine-University, Düsseldorf, Germany
contact email	polina.lipaeva@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD046654

PRIDE project URI

• PRIDE
  1. PXD046654
     1. Label: PRIDE project
     2. Name: Sustainability of specific improvements of cardiorespiratory fitness and insulin sensitive metabolism in type 2 diabetes after exercise training