⮝ Full datasets listing

PXD046626

PXD046626 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleInterorgan communication in the neurogenic heterotopic ossification: focusing on the role of brain-derived extracellular vesicles
DescriptionBrain-derived extracellular vesicles participate in inter-organ communication after traumatic brain injury by transporting pathogens to initiate secondary injury. Inflammasome related proteins encapsulated in brain-derived extracellular vesicles are capable of crossing the blood-brain barrier to reach distal tissues. These proteins initiate inflammatory dysfunction such as neurogenic heterotopic ossification. This recurrent condition is highly debilitating to patients because of its relatively unknown pathogenesis and the lack of effective prophylactic intervention strategies. Accordingly, a rat model of neurogenic heterotopic ossification that combined traumatic brain injury and achillotenotomy was developed to address these two issues. Histological examination of the injured tendon identified the coexistence of ectopic calcification and fibroblast pyroptosis. The relationships among brain-derived extracellular vesicles, fibroblast pyroptosis and ectopic calcification were further investigated in vitro and in vivo. Intravenous injection of the pyroptosis inhibitor Ac-YVAD-cmk reversed the development of neurogenic heterotopic ossification in vivo. The present work highlighted the role of brain-derived extracellular vesicles in the pathogenesis of neurogenic heterotopic ossification and offered a potential strategy for the prevention of neurogenic heterotopic ossification after traumatic brain injury.
HostingRepositoryiProX
AnnounceDate2023-11-02
AnnouncementXMLSubmission_2024-03-06_00:16:50.781.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHaoqing Xu
SpeciesList scientific name: Rattus rattus; NCBI TaxID: 10117;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Eclipse
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-11-02 19:57:06ID requested
12023-11-02 19:57:26announced
22024-03-06 00:16:52announced2024-03-06: Update information.
Publication List
Lu W, Yan J, Wang C, Qin W, Han X, Qin Z, Wei Y, Xu H, Gao J, Gao C, Ye T, Tay FR, Niu L, Jiao K, Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles. Bone Res, 12(1):11(2024) [pubmed]
Keyword List
submitter keyword: neurogenic heterotopic ossification, brain-derived extracellular vesicles, pyroptosis, traumatic brain injury
Contact List
Kai Jiao
contact affiliationAir Force Military Medical University
contact emailkjiao1@163.com
lab head
Haoqing Xu
contact affiliationAir Force Military Medical University
contact email1160476557@qq.com
dataset submitter
Full Dataset Link List
iProX dataset URI