PXD046626
PXD046626 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Interorgan communication in the neurogenic heterotopic ossification: focusing on the role of brain-derived extracellular vesicles |
Description | Brain-derived extracellular vesicles participate in inter-organ communication after traumatic brain injury by transporting pathogens to initiate secondary injury. Inflammasome related proteins encapsulated in brain-derived extracellular vesicles are capable of crossing the blood-brain barrier to reach distal tissues. These proteins initiate inflammatory dysfunction such as neurogenic heterotopic ossification. This recurrent condition is highly debilitating to patients because of its relatively unknown pathogenesis and the lack of effective prophylactic intervention strategies. Accordingly, a rat model of neurogenic heterotopic ossification that combined traumatic brain injury and achillotenotomy was developed to address these two issues. Histological examination of the injured tendon identified the coexistence of ectopic calcification and fibroblast pyroptosis. The relationships among brain-derived extracellular vesicles, fibroblast pyroptosis and ectopic calcification were further investigated in vitro and in vivo. Intravenous injection of the pyroptosis inhibitor Ac-YVAD-cmk reversed the development of neurogenic heterotopic ossification in vivo. The present work highlighted the role of brain-derived extracellular vesicles in the pathogenesis of neurogenic heterotopic ossification and offered a potential strategy for the prevention of neurogenic heterotopic ossification after traumatic brain injury. |
HostingRepository | iProX |
AnnounceDate | 2023-11-02 |
AnnouncementXML | Submission_2024-03-06_00:16:50.781.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Haoqing Xu |
SpeciesList | scientific name: Rattus rattus; NCBI TaxID: 10117; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Eclipse |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-11-02 19:57:06 | ID requested | |
1 | 2023-11-02 19:57:26 | announced | |
⏵ 2 | 2024-03-06 00:16:52 | announced | 2024-03-06: Update information. |
Publication List
Lu W, Yan J, Wang C, Qin W, Han X, Qin Z, Wei Y, Xu H, Gao J, Gao C, Ye T, Tay FR, Niu L, Jiao K, Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles. Bone Res, 12(1):11(2024) [pubmed] |
Keyword List
submitter keyword: neurogenic heterotopic ossification, brain-derived extracellular vesicles, pyroptosis, traumatic brain injury |
Contact List
Kai Jiao | |
---|---|
contact affiliation | Air Force Military Medical University |
contact email | kjiao1@163.com |
lab head | |
Haoqing Xu | |
contact affiliation | Air Force Military Medical University |
contact email | 1160476557@qq.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |