PXD046626

PXD046626 is an original dataset announced via ProteomeXchange.

Title	Interorgan communication in the neurogenic heterotopic ossification: focusing on the role of brain-derived extracellular vesicles
Description	Brain-derived extracellular vesicles participate in inter-organ communication after traumatic brain injury by transporting pathogens to initiate secondary injury. Inflammasome related proteins encapsulated in brain-derived extracellular vesicles are capable of crossing the blood-brain barrier to reach distal tissues. These proteins initiate inflammatory dysfunction such as neurogenic heterotopic ossification. This recurrent condition is highly debilitating to patients because of its relatively unknown pathogenesis and the lack of effective prophylactic intervention strategies. Accordingly, a rat model of neurogenic heterotopic ossification that combined traumatic brain injury and achillotenotomy was developed to address these two issues. Histological examination of the injured tendon identified the coexistence of ectopic calcification and fibroblast pyroptosis. The relationships among brain-derived extracellular vesicles, fibroblast pyroptosis and ectopic calcification were further investigated in vitro and in vivo. Intravenous injection of the pyroptosis inhibitor Ac-YVAD-cmk reversed the development of neurogenic heterotopic ossification in vivo. The present work highlighted the role of brain-derived extracellular vesicles in the pathogenesis of neurogenic heterotopic ossification and offered a potential strategy for the prevention of neurogenic heterotopic ossification after traumatic brain injury.
HostingRepository	iProX
AnnounceDate	2023-11-02
AnnouncementXML	Submission_2024-03-06_00:16:50.781.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Haoqing Xu
SpeciesList	scientific name: Rattus rattus; NCBI TaxID: 10117;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-02 19:57:06	ID requested
1	2023-11-02 19:57:26	announced
⏵ 2	2024-03-06 00:16:52	announced	2024-03-06: Update information.

Lu W, Yan J, Wang C, Qin W, Han X, Qin Z, Wei Y, Xu H, Gao J, Gao C, Ye T, Tay FR, Niu L, Jiao K, Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles. Bone Res, 12(1):11(2024) [pubmed]

submitter keyword: neurogenic heterotopic ossification, brain-derived extracellular vesicles, pyroptosis, traumatic brain injury

Kai Jiao
contact affiliation	Air Force Military Medical University
contact email	kjiao1@163.com
lab head
Haoqing Xu
contact affiliation	Air Force Military Medical University
contact email	1160476557@qq.com
dataset submitter

iProX dataset URI