PXD046625

PXD046625 is an original dataset announced via ProteomeXchange.

Title	The Quantitative Proteomics Analysis Reveals the Effect of a MarR Family Transcriptional Regulator AHA_2124 on Aeromonas hydrophila
Description	Transcription regulatory factors of MarR family play an important role in diverse bacterial physiologic functions, whereas the effect and its intrinsic regulatory mechanism on aquatic pathogenic bacteria Aeromonas hydrophila are still largely unknown. In this study, we firstly constructed a deletion strain of gene AHA_2124 (ΔAHA_2124) of a MarR family transcriptional regulator in A. hydrophila, and found that it had significantly enhanced hemolysis, extracellular protease, and motility activities. The differentially expressed proteins (DEPs) between wild-type and ΔAHA_2124 strain were compared by using the label-free based quantitative proteomics technology, and there were 178 DEPs including 80 proteins up-regulated and 98 proteins down-regulated. Bioinformatics analysis showed that the deletion of gene AHA_2124 led to some changes in the expression of proteins related to multiple biological processes, such as translation, peptide transport and oxidation reduction. These results provided a theoretical basis for better exploring the regulatory mechanism of transcriptional regulators of the MarR family of A. hydrophila on bacterial physiological functions.
HostingRepository	iProX
AnnounceDate	2023-11-02
AnnouncementXML	Submission_2024-02-18_19:01:09.262.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ziqiu Liu
SpeciesList	scientific name: Aeromonas hydrophila subsp. hydrophila ATCC 7966; NCBI TaxID: 380703;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-02 19:54:38	ID requested
1	2023-11-02 19:55:00	announced
⏵ 2	2024-02-18 19:01:10	announced	2024-02-19: Update Publication.

Li Z, Li W, Lu J, Liu Z, Lin X, Liu Y, . Biology (Basel), 12(12):(2023) [pubmed]

submitter keyword: Aeromonas hydrophila, MarR family transcriptional regulators, biological functions

Yanling Liu
contact affiliation	Fujian Agriculture and Forestry University
contact email	yanlingl@fafu.edu.cn
lab head
Ziqiu Liu
contact affiliation	Fujian Agriculture and Forestry University
contact email	460265004@qq.com
dataset submitter

iProX dataset URI