PXD046610
PXD046610 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomics analysis of tibialis anterior muscle and descending thoracic aorta from Mustn1 whole-body knockout mice and wild-type littermates |
Description | Skeletal muscle is a highly adaptive tissue that changes with many physiological stimuli and is composed of many cell types. Upon muscle injury, the concerted action of these cells is required to proceed through the process of inflammation, extracellular matrix remodeling, and restoration of function. To uncover novel genes and molecular pathways important for skeletal muscle remodeling and regeneration, we used a mouse hindlimb unloading and reloading protocol, and performed transcriptomics analysis. This study focuses on the microprotein Mustn1 (Musculoskeletal embryonic nuclear protein 1, also known as Mustang), whose gene expression is increased in muscle at the onset of hindlimb reloading, exercise, and injury. We generated a whole-body Mustn1 knockout mouse model and performed proteomics analysis of muscle and aorta. |
HostingRepository | PRIDE |
AnnounceDate | 2024-05-24 |
AnnouncementXML | Submission_2024-05-24_01:37:09.641.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Marta Murgia |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-11-02 08:15:10 | ID requested | |
⏵ 1 | 2024-05-24 01:37:10 | announced |
Publication List
Ducommun S, Jannig PR, Cervenka I, Murgia M, Mittenb, ü, hler MJ, Chernogubova E, Dias JM, Jude B, Correia JC, Van Vranken JG, Ocana-Santero G, Porsmyr-Palmertz M, McCann Haworth S, Mart, í, nez-Redondo V, Liu Z, Carlstr, ö, m M, Mann M, Lanner JT, Teixeira AI, Maegdefessel L, Spiegelman BM, Ruas JL, Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition. Mol Metab, 82():101912(2024) [pubmed] |
10.1016/j.molmet.2024.101912; |
Keyword List
submitter keyword: proteomics, aorta,Skeletal muscle, Mustn1 |
Contact List
Jorge L. Ruas | |
---|---|
contact affiliation | Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden |
contact email | jorge.ruas@ki.se |
lab head | |
Marta Murgia | |
contact affiliation | MPI Biochemistry |
contact email | mmurgia@biochem.mpg.de |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD046610 |
PRIDE project URI |
Repository Record List
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