PXD046603

PXD046603 is an original dataset announced via ProteomeXchange.

Title	ADP-heptose attenuates H. pylori-induced type I IFN signaling in DCs and impairs subsequent T cell responses
Description	Helicobacter pylori (H. pylori) colonizes the gastric mucosa of approximately 50% of the world’s population. While it is well established that H. pylori is a major cause of gastric cancer, it has only recently been reported that H. pylori can also have adverse effects on immunological processes, including autoimmune diseases and immunotherapies. Understanding the paradoxical interplay between H. pylori and the human immune system will therefore be beneficial to improve a variety of therapeutic approaches. Here we show that ADP-heptose, a metabolite originally reported to act as a bona fide PAMP, attenuates full-fledged activation of primary human dendritic cells in the context of H. pylori infection by impairing type I IFN signaling, which in turn results in reduced DC maturation and T cell activation. Thus, this study provides novel mechanistic insights into how H. pylori utilizes ADP-heptose to mitigate host immunity.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:58:11.438.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Veronika Schäpertöns
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-02 02:41:45	ID requested
1	2024-09-13 03:52:19	announced
⏵ 2	2024-10-22 06:58:11	announced	2024-10-22: Updated project metadata.

10.1080/19490976.2024.2402543;

submitter keyword: shotgun proteomics, cd8, adp heptose,Label-free quantification, h. pylori

Dr. Christof Regl, MSc
contact affiliation	Bioanalytical Research Labs, Department of Biosciences & Medical Biology, Universität Salzburg, Austria
contact email	christof.regl@plus.ac.at
lab head
Veronika Schäpertöns
contact affiliation	PLUS University of Salzburg
contact email	veronika.schaepertoens@protonmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD046603

PRIDE project URI

• PRIDE
  1. PXD046603
     1. Label: PRIDE project
     2. Name: ADP-heptose attenuates H. pylori-induced type I IFN signaling in DCs and impairs subsequent T cell responses