PXD046587

PXD046587 is an original dataset announced via ProteomeXchange.

Title	Post-transcriptional mechanisms modulate the consequences of adaptive copy number variation
Description	Copy-number variants (CNVs) are large-scale amplifications or deletions of DNA that can drive rapid adaptive evolution and result in large-scale changes in gene expression. Whereas alterations in the copy number of one or more genes within a CNV can confer a selective advantage, other genes within a CNV can decrease fitness when their dosage is changed. Dosage compensation - in which the gene expression output from multiple gene copies is less than expected - is one means by which an organism can mitigate the fitness costs of deleterious gene amplification. Previous research has shown evidence for dosage compensation at both the transcriptional level and at the level of protein expression; however, the extent of compensation differs substantially between genes, strains, and studies. Here, we investigated sources of dosage compensation at multiple levels of gene expression regulation by defining the transcriptome, translatome and proteome of experimentally evolved yeast (Saccharomyces cerevisiae) strains containing adaptive CNVs.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:13:39.986.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pieter Spealman
SpeciesList	scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-01 09:37:48	ID requested
1	2023-11-01 10:19:24	announced
⏵ 2	2024-10-22 06:13:40	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Long-term experimental evolution (LTEE), Glutamine-limited growth media, Copy-number variant (CNV),Saccharomyces cerevisiae, Orbitrap

David Gresham
contact affiliation	Professor of Biology, Center for Genomics and Systems Biology Vice Dean, Graduate School of Arts and Sciences New York University, 12 Waverly Pl, New York, Ny 10003
contact email	dgresham@nyu.edu
lab head
Pieter Spealman
contact affiliation	New York University
contact email	pspealman@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD046587

PRIDE project URI

• PRIDE
  1. PXD046587
     1. Label: PRIDE project
     2. Name: Post-transcriptional mechanisms modulate the consequences of adaptive copy number variation