PXD046576

PXD046576 is an original dataset announced via ProteomeXchange.

Title	Identification of Proteins in Streptococcus pneumoniae extracellular vesicles (pEVs)
Description	Extracellular vesicles (EVs) have recently garnered attention for their participation in host-microbe interactions in Streptococcus pneumoniae infections. However, the effect of pEVs on the disruption of alveolar epithelial barrier remain poorly understood. Our studies focus on EVs produced by Streptococcus pneumoniae (pEVs), and reveal that pEVs are internalized by alveolar epithelial cells. In vitro, pEVs induce autophagy activation in a dosage-dependent manner and decrease the alveolar epithelial barrier’s trans-epithelium electrical resistance (TEER). In addition, pEV-containing bacterial peotein serine/threonine-protein kinase StkP may act as an activator for Streptococcus pneumoniae-induced autophagy activation. When administered systemically in mice, Streptococcus pneumoniae wild type strain induced acute lung injury, the deletion of stkP deletion strain attenuated this injury. Taken together, pEVs cargos emerge as critical contributors to tissue damage in mammalian hosts.
HostingRepository	PRIDE
AnnounceDate	2023-12-13
AnnouncementXML	Submission_2023-12-12_18:34:00.741.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Luqing Cui
SpeciesList	scientific name: Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466); NCBI TaxID: 373153;
ModificationList	acetylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-01 06:30:16	ID requested
⏵ 1	2023-12-12 18:34:01	announced

Dataset with its publication pending

submitter keyword: Streptococcus pneumoniae

extracellular vesicles

4D lable free

Luqing Cui
contact affiliation	Huazhong agricultural university
contact email	cuiluqing0625@163.com
lab head
Luqing Cui
contact affiliation	Huazhong agricultural university
contact email	cuiluqing0625@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/12/PXD046576

PRIDE project URI

• PRIDE
  1. PXD046576
     1. Label: PRIDE project
     2. Name: Identification of Proteins in Streptococcus pneumoniae extracellular vesicles (pEVs)