PXD046558
PXD046558 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Effect of soluble egg antigen (SEA) from S. japonicum on gene expression in hepatic progenitor cells (HPC) cell line LE/6 and WB-F344 |
Description | Schistosomiasis is a serious but neglected tropical disease, which can cause granulomatous lesions and hepatic fibrosis. The egg-induced liver fibrosis is the primary cause of mortality and morbidity associated with this chronic disease. HPCs are a kind of stem cells with potentially bidirectional differentiation ability and interact with hepatic stellate cells during liver injury. We here reported the activation of HPCs during S. japonicum-induced liver fibrosis. SEA was used to stimulate HPC cell line LE/6 and WB-F344, and the differentiated gene expressions were shown to display the effect. Taken together, our data provides a moelcular framwork for SEA stimulation on HPCs during S. japonicum infection. |
HostingRepository | iProX |
AnnounceDate | 2023-11-01 |
AnnouncementXML | Submission_2024-04-07_20:59:21.978.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yua Yuan |
SpeciesList | scientific name: Rattus norvegicus; NCBI TaxID: 10116; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-10-31 19:52:39 | ID requested | |
⏵ 1 | 2024-04-07 20:59:22 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: schistosoma, liver fibrosis, hepatic progenitor cell |
Contact List
Qian Chen | |
---|---|
contact affiliation | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST) |
contact email | 601428533@qq.com |
lab head | |
Yua Yuan | |
contact affiliation | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST) |
contact email | m15521257192@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |