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PXD046558

PXD046558 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleEffect of soluble egg antigen (SEA) from S. japonicum on gene expression in hepatic progenitor cells (HPC) cell line LE/6 and WB-F344
DescriptionSchistosomiasis is a serious but neglected tropical disease, which can cause granulomatous lesions and hepatic fibrosis. The egg-induced liver fibrosis is the primary cause of mortality and morbidity associated with this chronic disease. HPCs are a kind of stem cells with potentially bidirectional differentiation ability and interact with hepatic stellate cells during liver injury. We here reported the activation of HPCs during S. japonicum-induced liver fibrosis. SEA was used to stimulate HPC cell line LE/6 and WB-F344, and the differentiated gene expressions were shown to display the effect. Taken together, our data provides a moelcular framwork for SEA stimulation on HPCs during S. japonicum infection.
HostingRepositoryiProX
AnnounceDate2023-11-01
AnnouncementXMLSubmission_2024-04-07_20:59:21.978.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYua Yuan
SpeciesList scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-10-31 19:52:39ID requested
12024-04-07 20:59:22announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: schistosoma, liver fibrosis, hepatic progenitor cell
Contact List
Qian Chen
contact affiliationTongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST)
contact email601428533@qq.com
lab head
Yua Yuan
contact affiliationTongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST)
contact emailm15521257192@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI