PXD046532

PXD046532 is an original dataset announced via ProteomeXchange.

Title	Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice
Description	Matrix metalloproteinase 12 (MMP12) is a macrophage-secreted protein that is massively upregulated as a pro-inflammatory factor in metabolic and vascular tissues of mice and humans suffering from cardiometabolic diseases (CMDs). However, the molecular mechanisms explaining the contributions of MMP12 to CMDs are still unclear.
HostingRepository	PRIDE
AnnounceDate	2023-12-06
AnnouncementXML	Submission_2023-12-05_16:06:52.922.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Monika Svecla
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-31 06:47:55	ID requested
⏵ 1	2023-12-05 16:06:53	announced

10.1186/S12933-023-02064-3;

submitter keyword: Matrix metalloproteinase 12, Ldlr-deficient mice,CMD, MMP12 deficiency, Proteomics

Giuseppe Danilo Norata
contact affiliation	Department of Pharmacological and Biomolecular Sciences (DiSFeB)
contact email	danilo.norata@unimi.it
lab head
Monika Svecla
contact affiliation	University of Milan
contact email	monika.svecla@unimi.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/12/PXD046532

PRIDE project URI

• PRIDE
  1. PXD046532
     1. Label: PRIDE project
     2. Name: Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice