PXD046517

PXD046517 is an original dataset announced via ProteomeXchange.

Title	Metabolic, Neurotoxic and Immunotoxic Effects of PFAAs and their Mixtures on the Proteome of Plasma and Head Kidney from Rainbow Trout
Description	PFAAs (Perfluoroalkyl acids) are a class of bioaccumulative, persistent and ubiquitous aquatic contaminants. A paucity of toxicological information exists for short chain PFAAs and PFAA mixtures. In order to address these knowledge gaps, we performed a 3-week, aqueous exposure of rainbow trout to 3 different concentrations of a PFAA mixture (50 - 500 ng/L) and individual PFAAs (25 nM of PFOS, PFOA, PFBS or PFBA). Untargeted proteomics and were conducted on the blood plasma and head kidney tissue to evaluate differences in biological effect for congeners and mixtures. The mixture and PFOS exposures significantly altered the abundances of many plasma proteins involved in lipid metabolism and the nervous system. The PFOA and high mixture treatments altered many kidney proteins involved in oxidative stress and inflammation. The findings emphasize the need for more toxicological testing of PFAA mixtures and their potential to cause metabolic dysregulation and neurotoxicity in fish.
HostingRepository	PanoramaPublic
AnnounceDate	2024-04-23
AnnouncementXML	Submission_2024-04-23_17:07:38.555.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Denina Simmons
SpeciesList	scientific name: Oncorhynchus mykiss; NCBI TaxID: 8022;
ModificationList	Phospho; Gln->pyro-Glu; Carbamyl; Carbamidomethyl; Oxidation
Instrument	6545 Q-TOF LC/MS

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-30 19:38:16	ID requested
⏵ 1	2024-04-23 17:07:39	announced

Pollard S, De Silva AO, Simmons DBD, Metabolic, neurotoxic and immunotoxic effects of PFAAs and their mixtures on the proteome of the head kidney and plasma from rainbow trout (Oncorhynchus mykiss). Sci Total Environ, 928():172389(2024) [pubmed]

submitter keyword: proteomics, blood plasma, head kidney, rainbow trout, PFAAs, Perfluoroalkyl acids

Denina Simmons
contact affiliation	Ontario Tech University
contact email	denina.simmons@ontariotechu.ca
lab head
Denina Simmons
contact affiliation	Ontario Tech University
contact email	denina.simmons@ontariotechu.ca
dataset submitter

Panorama Public dataset URI