PXD046510

PXD046510 is an original dataset announced via ProteomeXchange.

Title	Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV Infection
Description	People with HIV (PWH) experience an increased vulnerability to premature aging and inflammation-associated comorbidities, even when HIV replication is suppressed by antiretroviral therapy (ART). However, the factors that contribute to or are associated with this vulnerability remain uncertain. In the general population, alterations in the glycomes of circulating IgGs trigger inflammation and precede the onset of aging-associated diseases. Here, we investigate the IgG glycomes of cross-sectional and longitudinal samples from 1,216 women and men, both living with virally suppressed HIV and those without HIV. Our glycan-based machine learning models indicate that living with chronic HIV significantly accelerates the accumulation of pro-aging associated glycomic alterations. Consistently, PWH exhibit heightened expression of senescence associated glycan-degrading enzymes compared to their controls. These glycomic alterations correlate with elevated markers of inflammatory aging and the severity of comorbidities, potentially preceding the development of such comorbidities. Mechanistically, HIV-specific antibodies glycoengineered with these alterations exhibit reduced anti-HIV IgG-mediated innate immune functions. These findings hold significant potential for the development of glycomic based biomarkers and tools to identify and prevent premature aging and comorbidities in people living with chronic viral infections.
HostingRepository	PRIDE
AnnounceDate	2024-03-21
AnnouncementXML	Submission_2024-03-21_07:37:39.321.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD046510
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Sergei Shalygin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	complex glycosylation
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-30 14:51:59	ID requested
⏵ 1	2024-03-21 07:37:39	announced

10.6019/PXD046510;

submitter keyword: ADCP,HIV

Glycome

IgG

Inflammation

Aging

Biological age

Cancer

Subclinical 51 atherosclerosis, ADCC, ADCD

Mohamed Abdel-Mohsen
contact affiliation	PI The Wistar Institute, Philadelphia, PA, USA;
contact email	mmohsen@Wistar.org
lab head
Sergei Shalygin
contact affiliation	CCRC, UGA
contact email	ss29810@uga.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD046510
     1. Label: PRIDE project
     2. Name: Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV Infection