PXD046495 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia |
Description | Myopia has become the major cause of visual impairment worldwide. Although the pathogenesis of myopia remains controversial, proteomics studies suggest that dysregulation of retinal metabolism is potentially involved in the pathology of myopia. Lysine lactylation of proteins plays a key role in regulating cellular metabolism, but little is known about its role in the form-deprived myopic retina. In this study, we performed lactylation proteomic analysis of the retinas of form-deprived myopic guinea pigs and found downregulated levels of lactylation of metabolism-critical enzymes in the retina. As the first report on retinal lactylation in myopic eyes, this study provides a reliable basis for further studies on retinal lactylation in myopic eyes. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-17 |
AnnouncementXML | Submission_2024-10-17_02:37:49.664.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | jiaojiao Feng |
SpeciesList | scientific name: Cavia porcellus (Guinea pig); NCBI TaxID: 10141; |
ModificationList | lactic acid |
Instrument | timsTOF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-10-30 03:04:11 | ID requested | |
⏵ 1 | 2024-10-17 02:37:50 | announced | |
Publication List
10.1016/j.isci.2024.110606; |
Feng J, Chen X, Li R, Xie Y, Zhang X, Guo X, Zhao L, Xu Z, Song Y, Song J, Bi H, Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia. iScience, 27(9):110606(2024) [pubmed] |
Keyword List
submitter keyword: lysine lactylation, form-deprivation myopia, lactate,aerobic glycolysis, retina |
Contact List
Hongsheng Bi |
contact affiliation | Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine |
contact email | hongshengbi1@163.com |
lab head | |
jiaojiao Feng |
contact affiliation | Shandong University of Traditional Chinese Medicine |
contact email | szyykxfjj2021@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD046495 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046495
- Label: PRIDE project
- Name: Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia