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PXD046495

PXD046495 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia
DescriptionMyopia has become the major cause of visual impairment worldwide. Although the pathogenesis of myopia remains controversial, proteomics studies suggest that dysregulation of retinal metabolism is potentially involved in the pathology of myopia. Lysine lactylation of proteins plays a key role in regulating cellular metabolism, but little is known about its role in the form-deprived myopic retina. In this study, we performed lactylation proteomic analysis of the retinas of form-deprived myopic guinea pigs and found downregulated levels of lactylation of metabolism-critical enzymes in the retina. As the first report on retinal lactylation in myopic eyes, this study provides a reliable basis for further studies on retinal lactylation in myopic eyes.
HostingRepositoryPRIDE
AnnounceDate2024-10-17
AnnouncementXMLSubmission_2024-10-17_02:37:49.664.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterjiaojiao Feng
SpeciesList scientific name: Cavia porcellus (Guinea pig); NCBI TaxID: 10141;
ModificationListlactic acid
InstrumenttimsTOF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-10-30 03:04:11ID requested
12024-10-17 02:37:50announced
Publication List
10.1016/j.isci.2024.110606;
Feng J, Chen X, Li R, Xie Y, Zhang X, Guo X, Zhao L, Xu Z, Song Y, Song J, Bi H, Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia. iScience, 27(9):110606(2024) [pubmed]
Keyword List
submitter keyword: lysine lactylation, form-deprivation myopia, lactate,aerobic glycolysis, retina
Contact List
Hongsheng Bi
contact affiliationAffiliated Eye Hospital of Shandong University of Traditional Chinese Medicine
contact emailhongshengbi1@163.com
lab head
jiaojiao Feng
contact affiliationShandong University of Traditional Chinese Medicine
contact emailszyykxfjj2021@163.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
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