PXD046495

PXD046495 is an original dataset announced via ProteomeXchange.

Title	Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia
Description	Myopia has become the major cause of visual impairment worldwide. Although the pathogenesis of myopia remains controversial, proteomics studies suggest that dysregulation of retinal metabolism is potentially involved in the pathology of myopia. Lysine lactylation of proteins plays a key role in regulating cellular metabolism, but little is known about its role in the form-deprived myopic retina. In this study, we performed lactylation proteomic analysis of the retinas of form-deprived myopic guinea pigs and found downregulated levels of lactylation of metabolism-critical enzymes in the retina. As the first report on retinal lactylation in myopic eyes, this study provides a reliable basis for further studies on retinal lactylation in myopic eyes.
HostingRepository	PRIDE
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_02:37:49.664.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	jiaojiao Feng
SpeciesList	scientific name: Cavia porcellus (Guinea pig); NCBI TaxID: 10141;
ModificationList	lactic acid
Instrument	timsTOF

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-30 03:04:11	ID requested
⏵ 1	2024-10-17 02:37:50	announced

10.1016/j.isci.2024.110606;

Feng J, Chen X, Li R, Xie Y, Zhang X, Guo X, Zhao L, Xu Z, Song Y, Song J, Bi H, Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia. iScience, 27(9):110606(2024) [pubmed]

submitter keyword: lysine lactylation, form-deprivation myopia, lactate,aerobic glycolysis, retina

Hongsheng Bi
contact affiliation	Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine
contact email	hongshengbi1@163.com
lab head
jiaojiao Feng
contact affiliation	Shandong University of Traditional Chinese Medicine
contact email	szyykxfjj2021@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD046495

PRIDE project URI

• PRIDE
  1. PXD046495
     1. Label: PRIDE project
     2. Name: Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia