PXD046464 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Plasma proteomic analysis on neuropathic pain in idiopathic peripheral neuropathy patients |
Description | • Project description: Why only half of the idiopathic peripheral polyneuropathy (IPN) patients develop neuropathic pain is unknown. By conducting a proteomics analysis on IPN patients, we aimed to discover proteins and new pathways that are associated with neuropathic pain. We conducted unbiased mass-spectrometry proteomics analysis on blood plasma from 31 IPN patients with severe neuropathic pain and 29 IPN patients with no pain, to investigate protein biomarkers and protein-protein interactions associated with neuropathic pain. Univariate modeling was done with Linear mixed modeling (LMM) and corrected for multiple testing. Multivariate modelling was performed using elastic net analysis and validated with internal cross validation and bootstrapping. |
HostingRepository | PRIDE |
AnnounceDate | 2025-02-19 |
AnnouncementXML | Submission_2025-02-19_10:32:08.220.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Perry van Doormaal |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-10-27 09:52:32 | ID requested | |
⏵ 1 | 2025-02-19 10:32:09 | announced | |
Publication List
10.1111/jns.12606; |
van Doormaal PTC, Thomas S, Ajroud-Driss S, Cole RN, DeVine LR, Dimachkie MM, Geisler S, Freeman R, Simpson DM, Singleton JR, Smith AG, Stino A, H, ö, ke A, Plasma proteomic analysis on neuropathic pain in idiopathic peripheral neuropathy patients. J Peripher Nerv Syst, 29(1):88-96(2024) [pubmed] |
Keyword List
submitter keyword: LC-MSMS,proteomics, neuropathic pain, idiopathic peripheral neuropathy |
Contact List
Ahmet Hoke |
contact affiliation | Ahmet Hoke M.D., Ph.D. FRCPC Professor, Neurology and Neuroscience Director, Neuromuscular Division Director, Merkin Peripheral Neuropathy and Nerve Regeneration Center Editor-in-Chief, Experimental Neurology Johns Hopkins School of Medicine 855 N. Wolfe St., Rangos 248 Baltimore, MD, 21205 USA |
contact email | ahoke@jhmi.edu |
lab head | |
Perry van Doormaal |
contact affiliation | Johns Hopkins School of Medicine |
contact email | p.vandoormaal@umcutrecht.nl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/02/PXD046464 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046464
- Label: PRIDE project
- Name: Plasma proteomic analysis on neuropathic pain in idiopathic peripheral neuropathy patients