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PXD046464

PXD046464 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePlasma proteomic analysis on neuropathic pain in idiopathic peripheral neuropathy patients
Description• Project description: Why only half of the idiopathic peripheral polyneuropathy (IPN) patients develop neuropathic pain is unknown. By conducting a proteomics analysis on IPN patients, we aimed to discover proteins and new pathways that are associated with neuropathic pain. We conducted unbiased mass-spectrometry proteomics analysis on blood plasma from 31 IPN patients with severe neuropathic pain and 29 IPN patients with no pain, to investigate protein biomarkers and protein-protein interactions associated with neuropathic pain. Univariate modeling was done with Linear mixed modeling (LMM) and corrected for multiple testing. Multivariate modelling was performed using elastic net analysis and validated with internal cross validation and bootstrapping.
HostingRepositoryPRIDE
AnnounceDate2025-02-19
AnnouncementXMLSubmission_2025-02-19_10:32:08.220.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPerry van Doormaal
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-10-27 09:52:32ID requested
12025-02-19 10:32:09announced
Publication List
10.1111/jns.12606;
van Doormaal PTC, Thomas S, Ajroud-Driss S, Cole RN, DeVine LR, Dimachkie MM, Geisler S, Freeman R, Simpson DM, Singleton JR, Smith AG, Stino A, H, ö, ke A, Plasma proteomic analysis on neuropathic pain in idiopathic peripheral neuropathy patients. J Peripher Nerv Syst, 29(1):88-96(2024) [pubmed]
Keyword List
submitter keyword: LC-MSMS,proteomics, neuropathic pain, idiopathic peripheral neuropathy
Contact List
Ahmet Hoke
contact affiliationAhmet Hoke M.D., Ph.D. FRCPC Professor, Neurology and Neuroscience Director, Neuromuscular Division Director, Merkin Peripheral Neuropathy and Nerve Regeneration Center Editor-in-Chief, Experimental Neurology Johns Hopkins School of Medicine 855 N. Wolfe St., Rangos 248 Baltimore, MD, 21205 USA
contact emailahoke@jhmi.edu
lab head
Perry van Doormaal
contact affiliationJohns Hopkins School of Medicine
contact emailp.vandoormaal@umcutrecht.nl
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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