PXD046464

PXD046464 is an original dataset announced via ProteomeXchange.

Title	Plasma proteomic analysis on neuropathic pain in idiopathic peripheral neuropathy patients
Description	• Project description: Why only half of the idiopathic peripheral polyneuropathy (IPN) patients develop neuropathic pain is unknown. By conducting a proteomics analysis on IPN patients, we aimed to discover proteins and new pathways that are associated with neuropathic pain. We conducted unbiased mass-spectrometry proteomics analysis on blood plasma from 31 IPN patients with severe neuropathic pain and 29 IPN patients with no pain, to investigate protein biomarkers and protein-protein interactions associated with neuropathic pain. Univariate modeling was done with Linear mixed modeling (LMM) and corrected for multiple testing. Multivariate modelling was performed using elastic net analysis and validated with internal cross validation and bootstrapping.
HostingRepository	PRIDE
AnnounceDate	2025-02-19
AnnouncementXML	Submission_2025-02-19_10:32:08.220.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Perry van Doormaal
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-27 09:52:32	ID requested
⏵ 1	2025-02-19 10:32:09	announced

10.1111/jns.12606;

van Doormaal PTC, Thomas S, Ajroud-Driss S, Cole RN, DeVine LR, Dimachkie MM, Geisler S, Freeman R, Simpson DM, Singleton JR, Smith AG, Stino A, H, ö, ke A, Plasma proteomic analysis on neuropathic pain in idiopathic peripheral neuropathy patients. J Peripher Nerv Syst, 29(1):88-96(2024) [pubmed]

submitter keyword: LC-MSMS,proteomics, neuropathic pain, idiopathic peripheral neuropathy

Ahmet Hoke
contact affiliation	Ahmet Hoke M.D., Ph.D. FRCPC Professor, Neurology and Neuroscience Director, Neuromuscular Division Director, Merkin Peripheral Neuropathy and Nerve Regeneration Center Editor-in-Chief, Experimental Neurology Johns Hopkins School of Medicine 855 N. Wolfe St., Rangos 248 Baltimore, MD, 21205 USA
contact email	ahoke@jhmi.edu
lab head
Perry van Doormaal
contact affiliation	Johns Hopkins School of Medicine
contact email	p.vandoormaal@umcutrecht.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/02/PXD046464

PRIDE project URI

• PRIDE
  1. PXD046464
     1. Label: PRIDE project
     2. Name: Plasma proteomic analysis on neuropathic pain in idiopathic peripheral neuropathy patients