PXD046433

PXD046433 is an original dataset announced via ProteomeXchange.

Title	A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction
Description	Here we report the discovery of molecular glue degraders of the WIZ gene control factor that potentially and robustly induce HbF expression in preclinical models.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:49:05.919.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Amanda Hachey
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-26 17:31:14	ID requested
1	2024-07-08 08:30:53	announced
⏵ 2	2024-10-22 06:49:06	announced	2024-10-22: Updated project metadata.

10.1126/SCIENCE.ADK6129;

submitter keyword: LC-MS

Amanda Hachey
contact affiliation	Novartis Biomedical Research, Translational Profiling
contact email	amanda.hachey@novartis.com
lab head
Amanda Hachey
contact affiliation	NIBR
contact email	amanda.hachey@novartis.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD046433

PRIDE project URI

• PRIDE
  1. PXD046433
     1. Label: PRIDE project
     2. Name: A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction