PXD046422

PXD046422 is an original dataset announced via ProteomeXchange.

Title	Analysis of GITR and OX40 signaling complexes
Description	T cells are pivotal in the adaptive immune defense, necessitating a delicate balance between robust response against infections and self-tolerance. Their activation involves intricate cross-talk among signaling pathways triggered by the T-cell antigen receptors (TCR) and co-stimulatory or inhibitory receptors. The molecular regulation of these complex signaling networks is still incompletely understood. We identified an adaptor protein, ABIN1 as a component of the signaling complexes of GITR and OX40 co-stimulation receptors. T cells lacking ABIN1 exhibit hyper-responsiveness to TCR activation ex vivo, enhanced responses to cognate infections, and superior ability to induce experimental autoimmune diabetes in mice. We observed that ABIN1 negatively regulates NFκB and p38 pathways. The latter was at least partially responsible for the upregulation of key effector proteins, IFNG and GZMB in ABIN1-deficient T cells after TCR stimulation. Our findings reveal the intricate role of ABIN1 in T-cell regulation and its potential as a target for therapeutic fine-tuning T-cell responses.
HostingRepository	PRIDE
AnnounceDate	2024-04-25
AnnouncementXML	Submission_2024-04-25_05:14:42.920.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Peter Draber
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	methylthiolated residue; phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-26 08:09:04	ID requested
⏵ 1	2024-04-25 05:14:43	announced

Dataset with its publication pending

submitter keyword: T cells

co-stimulation

GITR

OX40

Abin1

MS

Peter Draber
contact affiliation	Laboratory of Immunity & Cell Communication, Division BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic
contact email	peter.draber@lf1.cuni.cz
lab head
Peter Draber
contact affiliation	BIOCEV, First Faculty of Medicine, Charles University
contact email	peter.draber@lf1.cuni.cz
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD046422
     1. Label: PRIDE project
     2. Name: Analysis of GITR and OX40 signaling complexes