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PXD046325

PXD046325 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis of the physiological E3 ubiquitin ligase responsible for PIN1 degradation
DescriptionInduced oncoproteins degradation provides an attractive anti-cancer modality. Activation of anaphase-promoting complex (APC/CCDH1) prevents cell cycle entry by targeting crucial mitotic proteins for degradation. Phosphorylation of its co-activator CDH1 modulates the E3 ligase activity, but little is known about its regulation after phosphorylation and how to effectively harness APC/CCDH1 activity to treat cancer. Notably, Proline-directed phosphorylation is regulated by PIN1-catalyzed cis-trans prolyl isomerization to drive tumor malignancy. However, the mechanisms controlling its protein turnover remain elusive. Through proteomic screens, we identify a reciprocal antagonism of PIN1-APC/CCDH1 mediated by domain-oriented phosphorylation-dependent dual interactions as a fundamental mechanism governing mitotic protein stability and cell cycle entry.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:31:54.835.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterWenxue Li
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-10-23 07:52:30ID requested
12024-02-28 12:30:53announced
22024-10-22 06:31:55announced2024-10-22: Updated project metadata.
Publication List
10.21203/rs.3.rs-2447544/v1;
Keyword List
submitter keyword: PIN1,Proteomics, CDH1
Contact List
Yansheng Liu
contact affiliationYale Cancer Biology Institute
contact emailyansheng.liu@yale.edu
lab head
Wenxue Li
contact affiliationYale University
contact emailwenxue.li@yale.edu
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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