PXD046324

PXD046324 is an original dataset announced via ProteomeXchange.

Title	Platelet Proteome in Myeloproliferative Neoplasms
Description	Patients with chronic Myeloproliferative Neoplasms (MPN) including polycythaemia vera (PV) and essential thrombocythemia (ET) exhibit unique clinical features, such as a tendency toward thrombosis and hemorrhage, and risk of disease progression to secondary bone marrow fibrosis and/or acute leukemia. Although an increase in blood cell lineage counts (quantitative features) contribute to these morbid sequelae, the significant qualitative abnormalities of myeloid cells that contribute to vascular risk are not well understood. Here, we address this critical knowledge gap via a comprehensive and untargeted profiling (using label free quantitative mass spectrometry) of the platelet proteome in a large (n= 140) cohort of patients (from two independent sites) with an established diagnosis of PV and ET. We discover distinct MPN platelet protein expression and confirm key molecular impairments associated with proteostasis and thrombosis mechanisms of potential relevance to MPN pathology.
HostingRepository	PRIDE
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_02:37:10.760.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sarah Kelliher
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Bruker Daltonics timsTOF series

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-23 07:47:28	ID requested
⏵ 1	2024-10-17 02:37:11	announced

10.1182/bloodadvances.2023012016;

Kelliher S, Gamba S, Weiss L, Shen Z, Marchetti M, Schieppati F, Scaife C, Madden S, Bennett K, Fortune A, Maung S, Fay M, N, í, , Á, inle F, Maguire P, Falanga A, Kevane B, Krishnan A, Platelet proteomic profiling reveals potential mediators of immunothrombosis and proteostasis in myeloproliferative neoplasms. Blood Adv, 8(16):4276-4280(2024) [pubmed]

submitter keyword: Platelet, Bruker TimsTOF, Data Dependant Acquisition, MPN, Myeloproliferative Neoplasms

Barry Kevane
contact affiliation	School of Medicine, University College Dublin
contact email	barrykevane@mater.ie
lab head
Sarah Kelliher
contact affiliation	School of Medicine, University College Dublin
contact email	sarah.kelliher@ucdconnect.ie
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD046324

PRIDE project URI

• PRIDE
  1. PXD046324
     1. Label: PRIDE project
     2. Name: Platelet Proteome in Myeloproliferative Neoplasms