PXD046311

PXD046311 is an original dataset announced via ProteomeXchange.

Title	The brain-blood-gut axis is associated with variability in stress sensitivity in mice
Description	Chronic stress can have lasting effects on some individuals, while there are other individuals who exhibit both susceptibility and resistance to the same stressor [43]. During stressful stimuli, resistant individuals exhibited weaker depression-like behaviors, while susceptible individuals showed increased depression-like behaviors. However, the causal relationship between individual behavioral differences and susceptibility and resistance is unclear. Here, we first distinguish between HPSM and LSPM behaviorally. Since gut research is also a new avenue for exploring behavioral changes, We found that susceptible and resistant mice are g-Desulfovibrio/g-Mycoplasma and its metabolite (tetrahydrocortisone/4,4-dimethyl-5alpha-cholinester-8,14, 24-triene-3 There was also a significant difference in the amount of beta-ol. Because gut bacteria are far from the brain, which has a tight blood-brain barrier. Metabolites, typically produced by gut microbes, first enter the bloodstream and then the brain, ultimately affecting behavior. The prefrontal cortex has long been the focus of stress research. We found that susceptible and resistant mice exhibited different behaviors before and after stress stimulation, and there were differences in the levels of a protein in the hippocampus (Ikbkb) of the brain. Because gut bacteria are far from the brain, and the brain has a tight blood-brain barrier. Metabolites, generally produced by gut microbes, first enter the bloodstream and then the brain, ultimately affecting behavior [46]. So we tried to detect lipid metabolites in plasma as a central axis substance connecting the gut-brain, and interestingly, in plasma, susceptibility and resistance mice also have differential lipids (LPC/SM/PI/TG). Together, these data provide a link between susceptibility and resistance and related behaviors during stressful experiences.
HostingRepository	iProX
AnnounceDate	2023-10-21
AnnouncementXML	Submission_2023-12-11_00:11:15.212.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	ChaoShuai Shang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-22 22:51:58	ID requested
1	2023-12-10 20:15:09	announced
⏵ 2	2023-12-11 00:11:15	announced	2023-12-11: Update information.

Dataset with its publication pending

submitter keyword: brain-blood-gut axis, stress sensitivity

Yajun Qiao
contact affiliation	Northwest Institute of Plateau Biology, Chinese Academy of Sciences
contact email	879316810@qq.com
lab head
ChaoShuai Shang
contact affiliation	Chinese Academy of Sciences
contact email	shchaoshuai@foxmail.com
dataset submitter

iProX dataset URI