PXD046300

PXD046300 is an original dataset announced via ProteomeXchange.

Title	Reversible phosphorylation of a lectin receptor-like kinase controls xylem immunity
Description	Pattern-recognition receptors (PRRs) mediate basal resistance to most phytopathogens. However, plant responses can be cell type-specific and the mechanisms governing xylem immunity remain largely unknown. We show that the lectin receptor-like kinase LORE contributes to xylem basal resistance in Arabidopsis upon infection with Ralstonia solanacearum, a destructive plant pathogen that colonizes the xylem to cause bacterial wilt. Following R. solanacearum infection, LORE is activated by phosphorylation at residue S761, initiating a phosphorelay that activates reactive oxygen species production and cell wall lignification. To prevent prolonged activation of immune signaling, LORE recruits and phosphorylates type 2C protein phosphatase LOPP, which dephosphorylates LORE and attenuates LORE-mediated xylem immunity to maintain immune homeostasis. A LOPP knockout confers resistance against bacterial wilt disease in Arabidopsis and tomatoes without impacting plant growth. Thus, our study reveals a regulatory mechanism in xylem immunity involving the reversible phosphorylation of receptor-like kinases
HostingRepository	iProX
AnnounceDate	2023-10-23
AnnouncementXML	Submission_2024-05-20_20:15:50.095.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ran Wang
SpeciesList	scientific name: Arabidopsis thaliana; NCBI TaxID: 3702;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-22 20:42:47	ID requested
1	2023-10-22 20:43:20	announced
⏵ 2	2024-05-20 20:15:50	announced	2024-05-21: Update information.

Wang R, Li C, Jia Z, Su Y, Ai Y, Li Q, Guo X, Tao Z, Lin F, Liang Y, Reversible phosphorylation of a lectin-receptor-like kinase controls xylem immunity. Cell Host Microbe, 31(12):2051-2066.e7(2023) [pubmed]

submitter keyword: xylem immunity, reactive oxygen species, reversible phosphorylation, lectin receptor-like kinase, Ralstonia solanacearum

Yan Liang
contact affiliation	Zhejiang University
contact email	yanliang@zju.edu.cn
lab head
Ran Wang
contact affiliation	Zhejiang University
contact email	wangran1263@163.com
dataset submitter

iProX dataset URI