PXD046259

PXD046259 is an original dataset announced via ProteomeXchange.

Title	Ejection of mitochondria and TNF-α activation mediate hypertonicity-induced adipocytes dedifferentiation
Description	Adipocyte extracellular vesicles and particles (EVs) proteomic profiling. In this study, we focus on the EVs proteomes changes induced by hypertonicity in 3T3-L1 and differentiated adipocytes. The source cells were cultured with isotonic/hypertonic medium for 48 hours, and EVs were isolated from the conditional medium using sequential ultracentrifugation. A label-free MS strategy was employed to achieve proteome identification and quantification.
HostingRepository	iProX
AnnounceDate	2023-10-20
AnnouncementXML	Submission_2024-02-22_19:51:08.559.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Liang Zhang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-20 05:00:24	ID requested
1	2023-10-20 05:02:18	announced
⏵ 2	2024-02-22 19:51:09	announced	2024-02-23: Update information.

Liu G, Wang Y, Pan Y, Tian L, Choi MH, Wang L, Kim JY, Zhang J, Cheng SH, Zhang L, -catenin signaling to promote adipocyte dedifferentiation. Stem Cell Res Ther, 14(1):333(2023) [pubmed]

submitter keyword: adipocyte, hypertonicity, EVs, mitochondria

Liang Zhang
contact affiliation	City Univeristy of Hong Kong
contact email	liangzhang.28@cityu.edu.hk
lab head
Liang Zhang
contact affiliation	City University of Hong Kong
contact email	liangzhang.28@cityu.edu.hk
dataset submitter

iProX dataset URI