PXD046234

PXD046234 is an original dataset announced via ProteomeXchange.

Title	New orphan disease therapies from the proteome of industrial plasma processing waste
Description	Plasma-derived therapeutic proteins are produced through an industrial fractionation process where proteins are purified from individual intermediates, some of which remain unused and are discarded. Relatively few plasma-derived proteins are exploited clinically, with most of available plasma being directed towards the manufacture of immunoglobulin and albumin. Although the plasma proteome provides opportunities to develop novel protein replacement therapies, particularly for rare diseases, the high cost of plasma together with small patient populations impact negatively on the development of plasma-derived orphan drugs. Enabling therapeutics development from unused plasma fractionation intermediates would therefore constitute a significant innovation. To this objective, we characterized the proteome of unused plasma fractionation intermediates and prioritized proteins for their potential as new candidate therapies for human disease.
HostingRepository	PRIDE
AnnounceDate	2024-01-23
AnnouncementXML	Submission_2024-01-23_09:12:16.904.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vittoria Cicaloni
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-19 03:25:57	ID requested
⏵ 1	2024-01-23 09:12:17	announced

10.1038/S42003-024-05820-7;

submitter keyword: Plasma, LC-MS/MS

Laura Salvini
contact affiliation	Mass Spectrometry Unit - Fondazione Toscana Life Sciences
contact email	l.salvini@toscanalifesciences.org
lab head
Vittoria Cicaloni
contact affiliation	Fondazione Toscana Life Sciences
contact email	v.cicaloni@toscanalifesciences.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD046234

PRIDE project URI

• PRIDE
  1. PXD046234
     1. Label: PRIDE project
     2. Name: New orphan disease therapies from the proteome of industrial plasma processing waste