PXD046193

PXD046193 is an original dataset announced via ProteomeXchange.

Title	Multi-omics analysis reveals concerted molecular responses to heat stress in a “red tide” dinoflagellate
Description	Harmful algal blooms are induced largely by nutrient enrichment common in warm waters. An increasingly frequent phenomenon is the “red tide”: blooms of dinoflagellate microalgae that accumulate toxins lethal to other organisms in high doses. Here, we present the de novo assembled genome (~4.75 Gbp) of Prorocentrum cordatum, a globally abundant, bloom-forming dinoflagellate, and the associated transcriptome, proteome, and metabolome data from axenic cultures to elucidate the microalgal molecular responses to heat stress. We discovered, in a high-G+C genome with long introns and extensive genetic duplication, a complementary mechanism between RNA editing and exon usage that regulates dynamic expression and functional diversity of genes and proteins, and metabolic profiles that reflect reduced capacities in photosynthesis, central metabolism, and protein synthesis. These results based on multi-omics evidence demonstrate the genomic hallmark of a bloom-forming dinoflagellate, and how the complex gene structures combined with multi-level transcriptional regulation underpin concerted heat-stress responses.
HostingRepository	PRIDE
AnnounceDate	2023-10-18
AnnouncementXML	Submission_2023-10-18_00:27:34.412.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	LarsWöhlbrand
SpeciesList	scientific name: Prorocentrum cordatum; NCBI TaxID: 2364126;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	amaZon Speed ETD

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-17 14:30:04	ID requested
⏵ 1	2023-10-18 00:27:34	announced

Dataset with its publication pending

submitter keyword: harmful algal bloo,Prorocentrum cordatum, Dinoflagellate

RalfRabus
contact affiliation	General and molecular microbiology, Institute for chemistry and biology of the marine environment (ICBM), Carl von Ossietzky University of Oldenburg, Oldenburg, Germany
contact email	rabus@icbm.de
lab head
LarsWöhlbrand
contact affiliation	General and Molecular Microbiology
contact email	lars.woehlbrand@uni-oldenburg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD046193

PRIDE project URI

• PRIDE
  1. PXD046193
     1. Label: PRIDE project
     2. Name: Multi-omics analysis reveals concerted molecular responses to heat stress in a “red tide” dinoflagellate