PXD046167 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Protein profile of purified plasma and aqueous humor-derived extracellular vesicles from patients with ocular toxoplasmosis |
| Description | To characterize extracellular vesicles proteins cargo from the aqueous humor and plasma of patients with ocular toxoplasmosis. Methods: Aqueous humor (AH) and plasma were collected from 6 patients with active ocular toxoplasmosis (OT) and 6 cataract patients (CAT). Extracellular vesicles (EVs) were isolated, and western blotting and mass spectrometry were performed for protein analysis. Results: All plasma samples from OT and CAT patients were positive for tetraspanins CD63 and TSG101 markers. However, only the AH from OT patients were positive for CD63. A total of 67 new proteins not previously reported in EVs were found in the AH and plasma from OT and CAT groups. Among these, 10 and 7 proteins were found only in the samples from CAT and OT groups, respectively. In general, these proteins were involved in immune system activation, retina homeostasis, factors related to infections and retina-associated disease. Conclusion: The distinct protein signatures between OT and CAT patients may be helpful in the differential diagnosis of OT. However, more studies are needed to better understand the role of these proteins in the pathogenesis of OT. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-10 |
| AnnouncementXML | Submission_2025-11-09_18:02:09.834.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Mohamed Abdouh |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; deamidated residue |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2023-10-16 13:46:50 | ID requested | |
| ⏵ 1 | 2025-11-09 18:02:12 | announced | |
Publication List
| 10.5935/0004-2749.2023-0037; |
| Costa DF, Pessuti CL, Tsering T, Abdouh M, Ribeiro K, Nascimento H, Commodaro AG, Burnier JV, Belfort R, Burnier MN, Protein profile of purified plasma- and aqueous humor-derived extracellular vesicles from patients with ocular toxoplasmosis. Arq Bras Oftalmol, 88(1):e20230037(2024) [pubmed] |
Keyword List
| submitter keyword: Extracellular Vesicles, Aqueous Humor |
| Plasma, Liquid Biopsy, Proteomics, Toxoplasma gondii, Ocular Toxoplasmosis |
Contact List
| Julia Burnier |
|---|
| contact affiliation | Scientist, IR-MUHC, Glen site Cancer Research Program Center for Translational Biology Assistant Professor, Gerald Bronfman Department of Oncology, Faculty of Medicine and Health Sciences, McGill University |
| contact email | julia.burnier@mcgill.ca |
| lab head | |
| Mohamed Abdouh |
|---|
| contact affiliation | Research Institute of the McGill University Health Centre |
| contact email | abdouhm2009@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046167
- Label: PRIDE project
- Name: Protein profile of purified plasma and aqueous humor-derived extracellular vesicles from patients with ocular toxoplasmosis
