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PXD046110

PXD046110 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleEnvironmental Enrichment and Rat Liver Proteomics
DescriptionWe aimed to address the challenge of accommodating an increasing demand for aged laboratory animals in the context of rising elderly population and research on aging-related diseases. We developed a cost-effective environmental enrichment method and assessed its impact on metabolic changes in Sprague Dawley rats' livers as a proof-of-concept organ. Twenty-four male rats were divided into four groups, with two kept in standard cages and two in modified rabbit cages. Half of each type of cage group received additional enrichment through weekly playtime in a larger cage. Over six months, the rats' weight gain was consistent across all groups, and corticosterone levels did not significantly differ. However, the control group had significantly lower DHEA and Testosterone levels at the study's end. Rats in enriched environments exhibited less distress during inspections and were more resistant to accepting treats. Animals accustomed to playpen time left their cages more easily. Overall, the study demonstrated that refining husbandry for aging rats is both simple and cost-effective, without detrimental effects on stress levels, development, or liver metabolism.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:24:30.682.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSimon Moosburner
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListNo PTMs are included in the dataset
Instrumentimpact II
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-10-13 03:51:27ID requested
12024-01-22 06:41:32announced
22024-10-22 06:24:31announced2024-10-22: Updated project metadata.
Publication List
10.1371/JOURNAL.PONE.0297497;
Keyword List
submitter keyword: Bile,Rat, Liver
Contact List
Prof. Dr. Igor M. Sauer
contact affiliationExperimental Surgery, Department of Surgery, Charité - Universitätsmedizin Berlin
contact emailigor.sauer@charite.de
lab head
Simon Moosburner
contact affiliationCharité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Surgery, Berlin, Germany
contact emailsimon.moosburner@charite.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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