PXD046053

PXD046053 is an original dataset announced via ProteomeXchange.

Title	Exploring the female genital tract mycobiome in young South African women using metaproteomics
Description	Female genital tract (FGT) diseases such as bacterial vaginosis (BV) and sexually transmitted infections are prevalent in South Africa, with young women being at an increased risk. Since imbalances in the FGT microbiome are associated with FGT diseases, it is vital to investigate the factors that influence FGT health. The mycobiome plays an important role in regulating mucosal health, especially when the bacterial component is disturbed. However, we have a limited understanding of the FGT mycobiome since many studies have focused on bacterial communities and have neglected low abundance taxonomic groups, such as fungi. To reduce this knowledge deficit, we present the first large-scale metaproteomic study to define the taxonomic composition and potential functional processes of the FGT mycobiome in South African reproductive-age women. We examined FGT fungal communities present in 123 women by collecting lateral vaginal wall swabs for liquid chromatography-tandem mass spectrometry.
HostingRepository	PRIDE
AnnounceDate	2025-03-28
AnnouncementXML	Submission_2025-03-28_03:02:29.264.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tamlyn Kirstey Gangiah
SpeciesList	scientific name: Neisseria gonorrhoeae; NCBI TaxID: NCBITaxon:485; scientific name: Chlamydia trachomatis; NCBI TaxID: NCBITaxon:813; scientific name: Trichomonas vaginalis; NCBI TaxID: NCBITaxon:5722; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-11 03:41:15	ID requested
⏵ 1	2025-03-28 03:02:29	announced

10.1186/S40168-025-02066-1;

submitter keyword: Human, Female genital tract, vaginal. LC-MS/MS

Lindi Masson
contact affiliation	Senior Research Fellow, Life Sciences Discipline, Burnet Institute, Australia
contact email	lindi.masson@burnet.edu.au
lab head
Tamlyn Kirstey Gangiah
contact affiliation	Swedish University of Agricultural Sciences
contact email	tamlyn.gangiah@slu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD046053

PRIDE project URI

• PRIDE
  1. PXD046053
     1. Label: PRIDE project
     2. Name: Exploring the female genital tract mycobiome in young South African women using metaproteomics