PXD046034

PXD046034 is an original dataset announced via ProteomeXchange.

Title	Adaptive epigenetic changes in histone variants and modifications rescue the fitness of Arabidopsis plants with dysfunctional histone chaperones
Description	The aim was to characterize histone variants and PTMs in mutant plants with histone chaperone dysfunction using mass spectrometry-based approach. We found that the maintenance of genome stability via chromatin remodelling depends on a two-tiered process. The first level relies on a highly flexible mechanism that involves alterations in histone marks while the second adaptive level requires assistance of histone chaperones for the replacement of specific histone variants which is a more time-consuming process.
HostingRepository	PRIDE
AnnounceDate	2024-10-07
AnnouncementXML	Submission_2024-10-07_13:50:51.190.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gabriela Lochmanova
SpeciesList	scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702;
ModificationList	monomethylated residue; phosphorylated residue; acetylated residue; N6,N6,N6-trimethyl-L-lysine; N6,N6-dimethyl-L-lysine
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-10 08:54:38	ID requested
⏵ 1	2024-10-07 13:50:52	announced

10.1016/j.mcpro.2024.100795;

Franek M, Ne, š, por Dadejov, á M, P, í, rek P, Kry, š, tofov, á K, Dobisov, á T, Zdr, á, hal Z, Dvo, ř, á, č, kov, á M, Lochmanov, á G, Histone Chaperone Deficiency in Arabidopsis Plants Triggers Adaptive Epigenetic Changes in Histone Variants and Modifications. Mol Cell Proteomics, 23(7):100795(2024) [pubmed]

submitter keyword: Arabidopsis, immunochemistry., post-translational modifications, mass spectrometry, histone chaperone complex,Chromatin remodeling, histone variants

Zbynek Zdrahal
contact affiliation	Mendel Center for Plant Genomics and Proteomics, Central European Institute of Technology, Brno, Czech Republic
contact email	Zdrahal@sci.muni.cz
lab head
Gabriela Lochmanova
contact affiliation	CEITEC-MU, Masaryk University, Brno
contact email	g.lochmanova@seznam.cz
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD046034

PRIDE project URI

• PRIDE
  1. PXD046034
     1. Label: PRIDE project
     2. Name: Adaptive epigenetic changes in histone variants and modifications rescue the fitness of Arabidopsis plants with dysfunctional histone chaperones