⮝ Full datasets listing

PXD046029

PXD046029 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDe novo identification of bacterial antigens of a clinical isolate by combining use of proteosurfaceomics, secretomics, and BacScan technologies
DescriptionEmerging infectious diseases pose a significant threat to both human and animal populations. Rapid de novo identification of protective antigens from a clinical isolate and development of an antigen-matched vaccine is a golden strategy to prevent the spread of emerging novel pathogens. Here, we have developed a universal pipeline by integrating proteosurfaceomics, secretomics, and BacScan technologies for the rapid de novo identification of bacterial protective proteins from a clinical isolate without prior knowledge of the pathogenic bacterium. As a proof of concept, we identified 3 novel protective proteins of A. pleuropneumoniae. Using the protective protein HBS1_14 and toxin proteins, we have developed a promising multivalent subunit vaccine against A. pleuropneumoniae. We believe that our strategy can be applied to any bacterial pathogen and has the potential to significantly accelerate the development of antigen-matched vaccines to prevent the spread of an emerging novel bacterial pathogen.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:15:32.616.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJinyue Yang
SpeciesList scientific name: Actinobacillus pleuropneumoniae; NCBI TaxID: 715;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-10-10 05:39:26ID requested
12023-11-21 19:34:57announced
22024-10-22 06:15:32announced2024-10-22: Updated project metadata.
Publication List
10.3389/FIMMU.2023.1274027;
Keyword List
submitter keyword: de novo identification, vaccine, A. pleuropneumoniae,Emerging bacterial pathogens, highly immunogenic proteins
Contact List
Pan Tao
contact affiliationHuazhong Agricultural University
contact emailtaopan@mail.hzau.edu.cn
lab head
Jinyue Yang
contact affiliationHuazhong Agricultural University
contact email1065367325@qq.com
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD046029
PRIDE project URI
Repository Record List
[ + ]