PXD046029 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | De novo identification of bacterial antigens of a clinical isolate by combining use of proteosurfaceomics, secretomics, and BacScan technologies |
Description | Emerging infectious diseases pose a significant threat to both human and animal populations. Rapid de novo identification of protective antigens from a clinical isolate and development of an antigen-matched vaccine is a golden strategy to prevent the spread of emerging novel pathogens. Here, we have developed a universal pipeline by integrating proteosurfaceomics, secretomics, and BacScan technologies for the rapid de novo identification of bacterial protective proteins from a clinical isolate without prior knowledge of the pathogenic bacterium. As a proof of concept, we identified 3 novel protective proteins of A. pleuropneumoniae. Using the protective protein HBS1_14 and toxin proteins, we have developed a promising multivalent subunit vaccine against A. pleuropneumoniae. We believe that our strategy can be applied to any bacterial pathogen and has the potential to significantly accelerate the development of antigen-matched vaccines to prevent the spread of an emerging novel bacterial pathogen. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:15:32.616.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jinyue Yang |
SpeciesList | scientific name: Actinobacillus pleuropneumoniae; NCBI TaxID: 715; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-10-10 05:39:26 | ID requested | |
1 | 2023-11-21 19:34:57 | announced | |
⏵ 2 | 2024-10-22 06:15:32 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: de novo identification, vaccine, A. pleuropneumoniae,Emerging bacterial pathogens, highly immunogenic proteins |
Contact List
Pan Tao |
contact affiliation | Huazhong Agricultural University |
contact email | taopan@mail.hzau.edu.cn |
lab head | |
Jinyue Yang |
contact affiliation | Huazhong Agricultural University |
contact email | 1065367325@qq.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD046029 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046029
- Label: PRIDE project
- Name: De novo identification of bacterial antigens of a clinical isolate by combining use of proteosurfaceomics, secretomics, and BacScan technologies