PXD046017

PXD046017 is an original dataset announced via ProteomeXchange.

Title	Genetic components of Escherichia coli involved in its complex preypredator interaction with Myxococcus xanthus
Description	Myxococcus xanthus and Escherichia coli represent a well-studied microbial predatorprey pair frequently examined in laboratory settings. While significant progress has been made in comprehending the mechanisms governing M. xanthus predation, various aspects of the response and defensive mechanisms of E. coli as prey remain elusive. In this study, the E. coli large-scale chromosome deletion library was screened, and a mutant designated as ME5012 was identified to possess remarkable resistance to predation by M. xanthus. Within the deleted region of ME5012 encompassing seven genes, the significance of dusB and fis genes in driving the observed resistant phenotype became apparent. Specifically, the deletion of fis resulted in a notable reduction in flagellum production in E. coli, contributing to a certain level of resistance against predation by M. xanthus. Meanwhile, the removal of dusB in E. coli led to diminished inducibility of myxovirescin A production by M. xanthus, accompanied by a slight increase in resistance to myxovirescin A. These findings shed light on the molecular mechanisms underlying the complex interaction between M. xanthus and E. coli in a predatory context.
HostingRepository	PRIDE
AnnounceDate	2024-01-26
AnnouncementXML	Submission_2024-01-26_09:41:14.531.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ning Zhang
SpeciesList	scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-10 00:23:32	ID requested
⏵ 1	2024-01-26 09:41:15	announced

Zhang N, Li T, Pan H, Wang Y, Li Q, Luan J, He X, Shi W, Li Y, Wang C, Zhang F, Hu W, . Front Microbiol, 14():1304874(2023) [pubmed]

10.3389/fmicb.2023.1304874;

submitter keyword: fis gene, Escherichia coli, predator-prey interaction, flagellum,Myxococcus xanthus, dusB gene, myxovirescin A

Ning Zhang
contact affiliation	Shandong University
contact email	yning_zhang08@mail.sdu.edu.cn
lab head
Ning Zhang
contact affiliation	Shandong University
contact email	yning_zhang08@mail.sdu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD046017

PRIDE project URI

• PRIDE
  1. PXD046017
     1. Label: PRIDE project
     2. Name: Genetic components of Escherichia coli involved in its complex preypredator interaction with Myxococcus xanthus