PXD045989 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | An unconventional integrin promotes human immunityAn unconventional integrin promotes human immunity |
Description | Cancer remains one of the leading causes of mortality worldwide, with increasing public health interest towards immunological-based approach in disease treatments. Enrichment of certain cell population, namely the CD103+ tissue-resident memory T (Trm) cells has been associated with better clinical prognosis in cancer as well as other inflammatory-diseased patients. However, the identity of specific biomarkers and mechanisms that can contribute towards protective immunity remains unclear. Here, we identified an unexpected CD61 expression on human cancer-specific CD103+ T cells, which formed unconventional transient pairing with CD103 on the synaptic microclusters following antigen recognition, through proteomics, synaptic microscopy and co-immunoprecipitation analyses. Further CD61 co-localisation with T cell receptor (TCR) at the synaptic centre demonstrated modulation of TCR signalling through specific adaptor proteins, which improves anti-tumor cytotoxicity and promote better physiological control of tumor growths in immunocompromised mouse model. Clinically, presence of CD61+ Trm cells are associated with improved patients’ outcome, mediated through enhanced effector functions and phenotypes whilst mitigating hallmarks of cellular exhaustion. This study identified an unconventional and transient CD61 expression and pairing with CD103 on human immune cells, which acts as an important pathway to mediate effective immunity, implicating a novel target for immune-based cellular therapies. |
HostingRepository | PRIDE |
AnnounceDate | 2024-07-30 |
AnnouncementXML | Submission_2024-07-30_03:10:32.748.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Adan Pinto-Fernandez |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-10-09 05:29:11 | ID requested | |
⏵ 1 | 2024-07-30 03:10:33 | announced | |
Publication List
Keyword List
submitter keyword: Human, Cancer Immunology, Interactomics |
Contact List
Adan Pinto-Fernandez |
contact affiliation | NDM-CAMS (COI) |
contact email | adan.pintofernandez@ndm.ox.ac.uk |
lab head | |
Adan Pinto-Fernandez |
contact affiliation | University of Oxford |
contact email | adan.pintofernandez@ndm.ox.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD045989 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD045989
- Label: PRIDE project
- Name: An unconventional integrin promotes human immunityAn unconventional integrin promotes human immunity