PXD045989

PXD045989 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	An unconventional integrin promotes human immunityAn unconventional integrin promotes human immunity
Description	Cancer remains one of the leading causes of mortality worldwide, with increasing public health interest towards immunological-based approach in disease treatments. Enrichment of certain cell population, namely the CD103+ tissue-resident memory T (Trm) cells has been associated with better clinical prognosis in cancer as well as other inflammatory-diseased patients. However, the identity of specific biomarkers and mechanisms that can contribute towards protective immunity remains unclear. Here, we identified an unexpected CD61 expression on human cancer-specific CD103+ T cells, which formed unconventional transient pairing with CD103 on the synaptic microclusters following antigen recognition, through proteomics, synaptic microscopy and co-immunoprecipitation analyses. Further CD61 co-localisation with T cell receptor (TCR) at the synaptic centre demonstrated modulation of TCR signalling through specific adaptor proteins, which improves anti-tumor cytotoxicity and promote better physiological control of tumor growths in immunocompromised mouse model. Clinically, presence of CD61+ Trm cells are associated with improved patients’ outcome, mediated through enhanced effector functions and phenotypes whilst mitigating hallmarks of cellular exhaustion. This study identified an unconventional and transient CD61 expression and pairing with CD103 on human immune cells, which acts as an important pathway to mediate effective immunity, implicating a novel target for immune-based cellular therapies.
HostingRepository	PRIDE
AnnounceDate	2024-07-30
AnnouncementXML	Submission_2024-07-30_03:10:32.748.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Adan Pinto-Fernandez
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-09 05:29:11	ID requested
⏵ 1	2024-07-30 03:10:33	announced

Publication List

10.1038/S41590-024-01802-3;

10.1038/S41590-024-01802-3;

Keyword List

submitter keyword: Human, Cancer Immunology, Interactomics

submitter keyword: Human, Cancer Immunology, Interactomics

Contact List

Adan Pinto-Fernandez
contact affiliation	NDM-CAMS (COI)
contact email	adan.pintofernandez@ndm.ox.ac.uk
lab head
Adan Pinto-Fernandez
contact affiliation	University of Oxford
contact email	adan.pintofernandez@ndm.ox.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD045989
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD045989

PRIDE project URI

Repository Record List

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