PXD045959

PXD045959 is an original dataset announced via ProteomeXchange.

Title	A quantitative proteomic study reveals oxidative stress and synaptic loss contributed to TDCIPP exposure induced memory impairment (2)
Description	Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) has been consistently identified in various environmental media and biological specimens. The current understanding of the in vivo toxicities of TDCIPP remains limited, especially for its neurotoxicity and cognitive impairment effects. To better evaluate the potential damage of TDCIPP on learning and memory, Sprague Dawley (SD) Rats were subjected to TDCIPP exposure at doses of 40, 120, and 360 mg/kg/day for a duration of 90 days. Quantitative proteomic analysis, immunohistochemistry, and western blotting techniques were employed to assess alterations in proteins following exposure to TDCIPP. Open field test and Morris Water Mase tests were used to assess anxiety and spatial learning memory capacity in rats. In the present study, it was observed that the administration of TDCIPP induced anxiety and cognitive impairments in rats. Additionally, a noteworthy decrease in the number of neurons was observed in the hippocampal CA3 and DG regions. Subsequent bioinformati
HostingRepository	iProX
AnnounceDate	2023-10-08
AnnouncementXML	Submission_2024-05-21_00:42:43.276.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Benhong Xu
SpeciesList	scientific name: Rattus rattus; NCBI TaxID: 10117;
ModificationList	TMT6plex reporter fragment
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-07 20:12:55	ID requested
⏵ 1	2024-05-21 00:42:44	announced

Zou C, Yang T, Zhang J, Chen X, Zhao J, Wu D, Yang C, Liu P, Huang X, Liu J, Xu B, A quantitative proteomic study reveals oxidative stress and synapse-related proteins contributed to TDCIPP exposure induced neurotoxicity. Ecotoxicol Environ Saf, 271():116005(2024) [pubmed]

submitter keyword: TDCIPP, Oxidative stress, Neurotoxicology

Benhong Xu
contact affiliation	Shenzhen Center for Disease Control and Prevention
contact email	xubenhong0916@163.com
lab head
Benhong Xu
contact affiliation	Shenzhen Center for Disease Control and Prevention
contact email	xubenhong0916@163.com
dataset submitter

iProX dataset URI