PXD045952
PXD045952 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Interaction of species A rotavirus VP4 with the cellular proteins vimentin and actin related protein 2 discovered by a proximity interactome assay |
| Description | Rotavirus (RV) is one of the most significant pathogens in humans and animals with diarrhea worldwide. Cell entry is the first step in viral infection, and the outer capsid protein VP4 is crucial for RV attachment and internalization. In order to discover novel candidate host factors involved in RV cell entry, a proximity labeling method was applied to systematically investigate the VP4 and host protein interactions. A total of 174 high confidence host proteins were identified using proximity labeling. Further analysis showed that 88 proteins were located in the cytoskeleton, plasma membrane, and extracellular region, which could be involved in RV entry. |
| HostingRepository | iProX |
| AnnounceDate | 2023-10-07 |
| AnnouncementXML | Submission_2024-02-18_20:23:16.474.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Chang Li |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-10-06 23:46:40 | ID requested | |
| 1 | 2023-10-07 01:01:51 | announced | |
| ⏵ 2 | 2024-02-18 20:23:17 | announced | 2024-02-19: Update Publication. |
Publication List
| Hao P, Qu Q, Pang Z, Li L, Du S, Shang L, Jin C, Xu W, Ha Z, Jiang Y, Chen J, Gao Z, Jin N, Wang J, Li C, Interaction of species A rotavirus VP4 with the cellular proteins vimentin and actin related protein 2 discovered by a proximity interactome assay. J Virol, 97(12):e0137623(2023) [pubmed] |
Keyword List
| submitter keyword: Rotavirus, VP4, VIM, ACTR2, Viral entry, proximity labeling |
Contact List
| Chang Li | |
|---|---|
| contact affiliation | Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun |
| contact email | lichang78@163.com |
| lab head | |
| Chang Li | |
| contact affiliation | Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun |
| contact email | lichang78@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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