PXD045937

PXD045937 is an original dataset announced via ProteomeXchange.

Title	Proteomic characteristics of serum from mice with alveolar echinococcosis
Description	Alveolar echinococcosis (AE) is a chronic and potentially fatal zoonotic parasitic disease that seriously affects the host's health. It is caused by the proliferation of Echinococcus multilocularis larvae within the liver. Due to its long incubation period following host infection, early diagnosis of the disease is currently not feasible. Treatment options are extremely limited, with the only choice being curative surgical resection combined with benzimidazole medication. Thus, the development of early, rapid, and minimally invasive diagnostic methods is crucial for enhancing patient prognosis. This study conducted a proteomic and metabolomic investigation into the alterations of proteins and metabolites in AE mouse serum, aiming to explore potential serum biomarkers. Twenty-two proteins exhibited significant differences between the treatment and control groups, primarily involved in carbohydrate metabolism, lipid metabolism, and amino acid metabolism. Upregulation of genes related to immune response and enhanced glycolysis were observed, possibly associated with the reproduction of E. multilocularis in the liver. A total of 182 metabolites were screened to distinguish between AE mice and healthy mice. A significant increase in cP450 metabolite of arachidonic acid indicated signs of renal and splenic involvement in AE mice. Furthermore, KEGG analysis suggested a close association between amino acid metabolism and the occurrence of AE. These data provide a promising avenue for the discovery of biomarkers and the study of potential etiological processes.
HostingRepository	iProX
AnnounceDate	2023-09-29
AnnouncementXML	Submission_2023-10-06_22:06:39.095.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiang Lu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-06 22:06:26	ID requested
⏵ 1	2023-10-06 22:06:39	announced

Dataset with its publication pending

submitter keyword: Echinococcus multilocularis

Xiao Ma
contact affiliation	Qinghai Institute of Endemic Disease Prevention and Control
contact email	maxiao0971@163.com
lab head
Xiang Lu
contact affiliation	Jiangsu University
contact email	lux9612@outlook.com
dataset submitter

iProX dataset URI