PXD045850

PXD045850 is an original dataset announced via ProteomeXchange.

Title	Mind Bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death
Description	Skin inflammation is a complex process implicated in various dermatological disorders. The chronic proliferative dermatitis (cpd) phenotype driven by the cpd mutation (cpdm) in the Sharpin gene is characterized by dermal inflammation and epidermal abnormalities. TNF and caspase-8-driven cell death causes the pathogenesis of Sharpincpdm mice, however, the role of MIB2, a pro-survival E3 ubiquitin ligase involved in TNF-signalling, in skin inflammation remains unknown. Here we demonstrate that MIB2 antagonises inflammatory dermatitis in the context of the cpd mutation. Surprisingly, the role of MIB2 in limiting skin inflammation is independent of its known pro-survival function and E3 ligase activity. Instead, MIB2 enhances the production of wound healing molecules, G-CSF and Eotaxin, within the skin. This discovery advances our comprehension of inflammatory cytokines and chemokines involved in cpdm pathogenesis, and highlights the significance of MIB2 in inflammatory skin disease that is independent of its ability to regulate TNF-induced cell death.
HostingRepository	PRIDE
AnnounceDate	2024-01-25
AnnouncementXML	Submission_2024-01-24_18:19:37.647.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Laura Dagley
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-02 06:59:45	ID requested
⏵ 1	2024-01-24 18:19:38	announced

10.1093/PNASNEXUS/PGAD438;

submitter keyword: Sharpin, TNF, cpdm, dermatitis,Mind Bomb 2

Rebecca Feltham
contact affiliation	Laboratory Head The Walter and Eliza Hall Institute of Medical Research 1G Royal Parade Parkville Victoria 3052 Australia
contact email	feltham.r@wehi.edu.au
lab head
Laura Dagley
contact affiliation	WEHI
contact email	dagley.l@wehi.edu.au
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD045850
     1. Label: PRIDE project
     2. Name: Mind Bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death