PXD045736

PXD045736 is an original dataset announced via ProteomeXchange.

Title	Progressive Supranuclear Palsy motor cortex
Description	Progressive Supranuclear palsy (PSP) is a 4-repeat (4-R) tauopathy. We hypothesized that the molecular diversity of tau could explain the heterogeneity seen in PSP disease progression. To test this hypothesis, we performed an extensive biochemical characterisation of the high molecular weight tau species (HMW-Tau) in 20 different brain regions of 25 PSP patients. To identify factors that contribute to these differences, we performed proteomic analysis that revealed key mechanistic pathways, in particular those involving the immune system, that defined patients demonstrating high and low tau seeding capacity.
HostingRepository	PRIDE
AnnounceDate	2025-10-03
AnnouncementXML	Submission_2025-10-03_10:13:55.590.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ivan Martinez-Valbuena
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-27 08:45:04	ID requested
⏵ 1	2025-10-03 10:13:55	announced

Dataset with its publication pending

submitter keyword: brain, motor cortex,human

Ivan Martinez Valbuena
contact affiliation	University of Toronto
contact email	ivan.martinez@utoronto.ca
lab head
Ivan Martinez-Valbuena
contact affiliation	Tanz Centre for Research in Neurodegenerative Diseases University of Toronto
contact email	ivan.martinez@utoronto.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD045736

PRIDE project URI

• PRIDE
  1. PXD045736
     1. Label: PRIDE project
     2. Name: Progressive Supranuclear Palsy motor cortex