⮝ Full datasets listing
PXD045633
PXD045633 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Deciphering the Mechanistic Activity of Human Milk Oligosaccharides against Group B Streptococcus using Multi-omics Techniques |
| Description | Human breast milk provides complete nutrition for the infant for up to six months of life. Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk, yet do not provide any nutritional benefit to the infant. HMOs serve as antiadhesives, preventing pathogenic colonization while acting as prebiotics for commensal bacteria. Prior research indicates that HMOs are beneficial outside the infant gut, with demonstrations of antibiofilm and antimicrobial activity against a myriad of pathogens. One such opportunistic pathogen, Group B Streptococcus (GBS), is known to cause invasive infection leading to adverse pregnancy outcomes, such as preterm birth and sepsis. Patients carrying GBS during gestation are dosed with antibiotics during labor, but with high prevalence of antibiotic resistance, novel therapeutics are needed. Before HMOs could be considered for their therapeutic potential, their mechanism of action must be uncovered. To bridge this gap, we present the first culmination of multi-omics data using metabolomics, transcriptomics, and proteomics to reveal how GBS responds to HMO exposure. HMOs function by disturbing several pathways, with highest impact on cell membrane/wall composition and construction, virulence factor production, metabolism, and stress response. These broader -omics studies open the door to more specific assays, with a goal of elucidating the mechanism of action of HMOs against GBS. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-03-23 |
| AnnouncementXML | Submission_2026-03-23_15:32:36.210.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lee Cantrell |
| SpeciesList | scientific name: Group B Streptococcus; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | instrument model |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-09-24 23:59:18 | ID requested | |
| ⏵ 1 | 2026-03-23 15:32:36 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Human Milk Oligosaccharides, Multi-omics, Streptococcus Infection |
Contact List
| Julie Talbert | |
|---|---|
| contact affiliation | Vanderbilt University |
| contact email | julie.a.talbert@vanderbilt.edu |
| lab head | |
| Lee Cantrell | |
| contact affiliation | Vanderbilt University |
| contact email | lee.s.cantrell@vanderbilt.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v06/MSV000092951/ |
