PXD045583
PXD045583 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Plasma Proteome Profiling Identified thrombospondin-1 and lactoferrin as Biomarkers of Relapsed Multiple Myeloma |
| Description | In this study, serum from bone marrow and peripheral blood was collected from patients with newly diagnosed MM (NDMM), RRMM, and MM in remission as well as healthy controls. Mass spectrometry-based tandem mass tag-labeled quantitative proteomics was applied to measure the levels of more than 1000 proteins in the serum. The results revealed the low expression of thrombospondin-1 (THBS1) and lactoferrin (LTF) in the bone marrow serum of patients with RRMM, indicating that these proteins are associated with MM relapse. The enzyme-linked immunosorbent assay (ELISA) results also revealed that THBS1 and LTF were downregulated in the bone marrow serum of patients with RRMM compared with the findings in patients with NDMM, and their levels in peripheral blood serum in the RRMM group were much lower than those in the NDMM, MM in remission, and healthy control groups. Based on the proteomics and ELISA data, the protein signature THBS1/LTF could contribute to the prediction of MM relapse. |
| HostingRepository | iProX |
| AnnounceDate | 2023-09-22 |
| AnnouncementXML | Submission_2023-09-22_02:27:03.301.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xiaoxiao Wu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | TMT6plex reporter+balance reagent acylated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-09-22 02:26:46 | ID requested | |
| ⏵ 1 | 2023-09-22 02:27:03 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: THBS1, LTF, relapsed/refractory myeloma |
Contact List
| Xiaoxiao Wu | |
|---|---|
| contact affiliation | National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College |
| contact email | 824638545@qq.com |
| lab head | |
| Xiaoxiao Wu | |
| contact affiliation | National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College |
| contact email | 824638545@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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