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PXD045583

PXD045583 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePlasma Proteome Profiling Identified thrombospondin-1 and lactoferrin as Biomarkers of Relapsed Multiple Myeloma
DescriptionIn this study, serum from bone marrow and peripheral blood was collected from patients with newly diagnosed MM (NDMM), RRMM, and MM in remission as well as healthy controls. Mass spectrometry-based tandem mass tag-labeled quantitative proteomics was applied to measure the levels of more than 1000 proteins in the serum. The results revealed the low expression of thrombospondin-1 (THBS1) and lactoferrin (LTF) in the bone marrow serum of patients with RRMM, indicating that these proteins are associated with MM relapse. The enzyme-linked immunosorbent assay (ELISA) results also revealed that THBS1 and LTF were downregulated in the bone marrow serum of patients with RRMM compared with the findings in patients with NDMM, and their levels in peripheral blood serum in the RRMM group were much lower than those in the NDMM, MM in remission, and healthy control groups. Based on the proteomics and ELISA data, the protein signature THBS1/LTF could contribute to the prediction of MM relapse.
HostingRepositoryiProX
AnnounceDate2023-09-22
AnnouncementXMLSubmission_2023-09-22_02:27:03.301.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterXiaoxiao Wu
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListTMT6plex reporter+balance reagent acylated residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-09-22 02:26:46ID requested
12023-09-22 02:27:03announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: THBS1, LTF, relapsed/refractory myeloma
Contact List
Xiaoxiao Wu
contact affiliationNational Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
contact email824638545@qq.com
lab head
Xiaoxiao Wu
contact affiliationNational Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
contact email824638545@qq.com
dataset submitter
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iProX dataset URI