PXD045557

PXD045557 is an original dataset announced via ProteomeXchange.

Title	Proteomic changes in lens of diabetic, age-related and post-vitrectomy cataract.
Description	The focus of our research centers on exploring the proteome changes and corresponding signaling pathways involved in the development of diabetic cataract, age-related cataract and post-vitrectomy cataract, investigating aqueous humor, anterior capsule and lens human samples. Outstanding proteomic profiles of the three sample types have been generated using DIA proteomics. We have observed substantial differences in the regulation of several pathways between our groups and samples types, and we have particularly highlighted the involvement of non-canonical Wnt receptor signaling pathway, glycosaminoglycan and glycosphingolipid pathways, and oxidation reduction pathway in the formation of different cataract forms.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_12:24:14.738.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martina Samiotaki
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-21 05:10:37	ID requested
⏵ 1	2025-05-06 12:24:15	announced

10.3390/jcm13237287;

Karakosta C, Samiotaki M, Panayotou G, Papaconstantinou D, Moschos MM, Proteomic Changes of Glycolipid Pathways in Age-Related, Diabetic, and Post-Vitrectomy Cataracts. J Clin Med, 13(23):(2024) [pubmed]

submitter keyword: Cataract, Aging, Vitrectomy, Diabetes, Crystallin, Cytoskeleton, Lens, Proteomics

Christina Karakosta
contact affiliation	School of Medicine, National Kapodistrian University of Athens, Mikras Asias 75, Athens 115 27, Greece
contact email	ckarakosta@med.uoa.gr
lab head
Martina Samiotaki
contact affiliation	Protein Analysis Laboratory B.S.R.C. "Alexander Fleming", Alexander Fleming Street 34 16672, Vari, Greece
contact email	samiotaki@fleming.gr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD045557

PRIDE project URI

• PRIDE
  1. PXD045557
     1. Label: PRIDE project
     2. Name: Proteomic changes in lens of diabetic, age-related and post-vitrectomy cataract.