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PXD045547

PXD045547 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic changes in anterior capsule of diabetic, age-related and post-vitrectomy cataract.
DescriptionThe focus of our research centers on exploring the proteome changes and corresponding signaling pathways involved in the development of diabetic cataract, age-related cataract and post-vitrectomy cataract, investigating aqueous humor, anterior capsule and lens human samples. Outstanding proteomic profiles of the three sample types have been generated using DIA proteomics. We have observed substantial differences in the regulation of several pathways between our groups and samples types, and we have particularly highlighted the involvement of non-canonical Wnt receptor signaling pathway, glycosaminoglycan and glycosphingolipid pathways, and oxidation reduction pathway in the formation of different cataract forms.
HostingRepositoryPRIDE
AnnounceDate2025-05-06
AnnouncementXMLSubmission_2025-05-06_12:24:08.683.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMartina Samiotaki
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-09-21 01:35:02ID requested
12025-05-06 12:24:09announced
Publication List
10.3390/jcm13237287;
Karakosta C, Samiotaki M, Panayotou G, Papaconstantinou D, Moschos MM, Proteomic Changes of Glycolipid Pathways in Age-Related, Diabetic, and Post-Vitrectomy Cataracts. J Clin Med, 13(23):(2024) [pubmed]
Keyword List
submitter keyword: Anterior Capsule,Cataract, Aging, Vitrectomy, Diabetes, Crystallin, Cytoskeleton, Proteomics
Contact List
Christina Karakosta
contact affiliationSchool of Medicine, National Kapodistrian University of Athens, Mikras Asias 75, Athens 115 27, Greece
contact emailckarakosta@med.uoa.gr
lab head
Martina Samiotaki
contact affiliationProtein Analysis Laboratory B.S.R.C. "Alexander Fleming", Alexander Fleming Street 34 16672, Vari, Greece
contact emailsamiotaki@fleming.gr
dataset submitter
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Dataset FTP location
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