PXD045513

PXD045513 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Ola1p trafficking indicates an interaction network between mitochondria, Lipid droplets and stress granules in times of stress
Description	Protein aggregates arise naturally under normal physiological conditions, but their formation is accelerated by age or stress-induced protein misfolding. One of the proteins that accumulate upon stress in yeast cells is Ola1p, know as the “super aggregator” Using a proximity labelling approach based upon the biotin ligase TurboID we were able to show that these Ola1p harbouring aggregates are, in fact, stress granules that interact with both mitochondria and LDs.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:25:49.387.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD045513
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Peter Briza
SpeciesList	scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-20 03:04:05	ID requested
1	2024-01-26 06:59:42	announced
⏵ 2	2024-10-22 06:25:54	announced	2024-10-22: Updated project metadata.

Publication List

Kovacs M, Geltinger F, Schartel L, P, ö, schl S, Briza P, Paschinger M, Boros K, Felder TK, Wimmer H, Duschl J, Rinnerthaler M, Ola1p trafficking indicates an interaction network between mitochondria, lipid droplets, and stress granules in times of stress. J Lipid Res, 64(12):100473(2023) [pubmed]
10.6019/PXD045513;
10.1016/j.jlr.2023.100473;

Kovacs M, Geltinger F, Schartel L, P, ö, schl S, Briza P, Paschinger M, Boros K, Felder TK, Wimmer H, Duschl J, Rinnerthaler M, Ola1p trafficking indicates an interaction network between mitochondria, lipid droplets, and stress granules in times of stress. J Lipid Res, 64(12):100473(2023) [pubmed]

10.6019/PXD045513;

10.1016/j.jlr.2023.100473;

Keyword List

submitter keyword: protein detoxification
protein aggregation
protein shuttling
stress response: Lipid droplets
mitochondria
proximity labelling
TurboID

submitter keyword: protein detoxification

protein aggregation

protein shuttling

stress response: Lipid droplets

mitochondria

proximity labelling

TurboID

Contact List

Peter Briza
contact affiliation	University of Salzburg, Department of Biosciences and Medical Biology, Salzburg, Austria
contact email	peter.briza@plus.ac.at
lab head
Peter Briza
contact affiliation	University of Salzburg
contact email	peter.briza@plus.ac.at
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD045513
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD045513

PRIDE project URI

Repository Record List

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