PXD045506

PXD045506 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Branched N-glycan of PD-L1 predicts immunotherapy responses in patients with recurrent/metastatic HNSCC
Description	Immunotherapy has revolutionized cancer treatment, however, a reliable biomarker is missing. MGAT5-mediated PD-L1 glycosylation is critical for its interaction with PD-1. MGAT5 expression is a functional biomarker that predicts immunotherapy responses.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_11:40:32.004.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD045506
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Hsin-Yi Wu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	N-glycosylated residue
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-19 22:55:44	ID requested
⏵ 1	2025-05-06 11:40:32	announced

Publication List

Huang HC, Huang YL, Chen YJ, Wu HY, Hsu CL, Kao HF, Liao BC, Hsieh MS, Lin NY, Liao YH, Chen HL, Chen CN, Chen TC, Wang CP, Yang TL, Huang MC, Lin MC, Lou PJ, The branched N-glycan of PD-L1 predicts immunotherapy responses in patients with recurrent/metastatic HNSCC. Oncogenesis, 13(1):36(2024) [pubmed]
10.6019/PXD045506;
10.1038/s41389-024-00532-3;

Huang HC, Huang YL, Chen YJ, Wu HY, Hsu CL, Kao HF, Liao BC, Hsieh MS, Lin NY, Liao YH, Chen HL, Chen CN, Chen TC, Wang CP, Yang TL, Huang MC, Lin MC, Lou PJ, The branched N-glycan of PD-L1 predicts immunotherapy responses in patients with recurrent/metastatic HNSCC. Oncogenesis, 13(1):36(2024) [pubmed]

10.6019/PXD045506;

10.1038/s41389-024-00532-3;

Keyword List

submitter keyword: MGAT5,Immunotherapy, N-glycosylation, PD-L1, Head and neck squamous cell carcinoma (HNSCC)

submitter keyword: MGAT5,Immunotherapy, N-glycosylation, PD-L1, Head and neck squamous cell carcinoma (HNSCC)

Contact List

Min-Chuan Huang
contact affiliation	Graduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University. Taipei, Taiwan
contact email	mchuang@ntu.edu.tw
lab head
Hsin-Yi Wu
contact affiliation	National Taiwan University
contact email	clairewu.wu@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD045506
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD045506

PRIDE project URI

Repository Record List

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