PXD045505

PXD045505 is an original dataset announced via ProteomeXchange.

Title	Exploration of Mycobacterium tuberculosis CYP138 Function by Quantitative proteome
Description	With the widespread of drug-resistant Mycobacterium tuberculosis (Mtb), anti-TB drugs with novel structures and targets are urgently needed to prevent the prevalence of drug-resistant strains. For the past few decades, many Mtb CYPs been structurally and functionally characterized, and some of them were proved to be potential drug targets. CYP138 belongs to the Mtb CYPs whose structures and functions are still unclear. In our study, to discover differentially expressed proteins, a cyp138-knockout strain was built, and the function of CYP138 was speculated by the comparison between cyp138-knockout and wild-type strains through 6-plex TMT-labeling-based quantitative proteomic approach.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:32:38.541.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yun Lu
SpeciesList	scientific name: Mycobacterium tuberculosis H37Rv; NCBI TaxID: 83332;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-19 22:18:13	ID requested
1	2024-03-10 09:06:53	announced
⏵ 2	2024-10-22 06:32:38	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Mycobacterium tuberculosis/ CYP138/gene knock-down/comparative proteome

Xuefu You
contact affiliation	Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College
contact email	xuefuyou@hotmail.com
lab head
Yun Lu
contact affiliation	Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College
contact email	yunluly@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/03/PXD045505

PRIDE project URI

• PRIDE
  1. PXD045505
     1. Label: PRIDE project
     2. Name: Exploration of Mycobacterium tuberculosis CYP138 Function by Quantitative proteome