PXD045505 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Exploration of Mycobacterium tuberculosis CYP138 Function by Quantitative proteome |
Description | With the widespread of drug-resistant Mycobacterium tuberculosis (Mtb), anti-TB drugs with novel structures and targets are urgently needed to prevent the prevalence of drug-resistant strains. For the past few decades, many Mtb CYPs been structurally and functionally characterized, and some of them were proved to be potential drug targets. CYP138 belongs to the Mtb CYPs whose structures and functions are still unclear. In our study, to discover differentially expressed proteins, a cyp138-knockout strain was built, and the function of CYP138 was speculated by the comparison between cyp138-knockout and wild-type strains through 6-plex TMT-labeling-based quantitative proteomic approach. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:32:38.541.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yun Lu |
SpeciesList | scientific name: Mycobacterium tuberculosis H37Rv; NCBI TaxID: 83332; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-09-19 22:18:13 | ID requested | |
1 | 2024-03-10 09:06:53 | announced | |
⏵ 2 | 2024-10-22 06:32:38 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Mycobacterium tuberculosis/ CYP138/gene knock-down/comparative proteome |
Contact List
Xuefu You |
contact affiliation | Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College |
contact email | xuefuyou@hotmail.com |
lab head | |
Yun Lu |
contact affiliation | Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College |
contact email | yunluly@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD045505
- Label: PRIDE project
- Name: Exploration of Mycobacterium tuberculosis CYP138 Function by Quantitative proteome