PXD045469

PXD045469 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of plasma in patients with osteoarthritis and hemophilic arthropathy
Description	Osteoarthritis (OA) and hemophilic arthropathy (HA) are clinically similar, but pathologically distinct conditions which result in joint pain and loss of function. Distinguishing their disease mechanisms is therefore a key step in the development of curative therapy, as opposed to current symptomatic treatments. Aim: To investigate the potential differences in plasma proteomic profile between OA and HA patients. Methods: This pilot cross-sectional study includes N=40 male participants equally divided across 4 subgroups: 1-2/haemophilia patients with severe or mild HA and 3-4/control subjects with severe or mild/no OA. We pooled plasma samples from each stage to search for biomarkers that accurately present each condition in order to achieve a biological sample which would represent a “biological average” as much as possible (1,2). The protein profile will be determined using liquid chromatography / mass spectrometry, after which functional gene enrichment analysis will be performed. Conclusion: The goal of the study is to uncover marked differences in plasma proteomic profile in patients with HA vs. OA which will potentially shed new light on the mechanisms of HA pathogenesis and could identify potential molecular therapeutic or diagnostic targets.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_12:04:49.903.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Václav Pustka
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-18 08:59:38	ID requested
⏵ 1	2025-05-06 12:04:50	announced

10.1002/hsr2.70046;

Kalebota N, Novak R, Hrka, č S, Peri, ć P, Salai G, Mo, č, ibob M, Pranji, ć M, Zdr, á, hal Z, Pustka V, Ž, erjavi, ć NL, Milo, š, evi, ć M, Vodanovi, ć M, Š, alek SZ, Grgurevi, ć L, Proteomic exploration of potential blood biomarkers in haemophilic arthropathy. Health Sci Rep, 7(9):e70046(2024) [pubmed]

submitter keyword: disease biomarkers, proteomics,haemophilic arthropathy, haemophilia

Zbynek Zdrahal
contact affiliation	Proteomics Core Facility and Research Group Proteomics, CEITEC-MU, Masaryk University, Brno, Czech Republic
contact email	zdrahal@sci.muni.cz
lab head
Václav Pustka
contact affiliation	Proteomics Core Facility and Research Group Proteomics CEITEC-MU Masaryk University Brno, Czech Republic
contact email	vaclav.pustka@ceitec.muni.cz
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD045469
     1. Label: PRIDE project
     2. Name: Proteomic profiling of plasma in patients with osteoarthritis and hemophilic arthropathy