PXD045445 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Metabolic Roadmap to Nephrogenesis |
Description | CKD and hypertension to impact a staggering 1.5 billion individuals within the next decade. Optimal fetal growth and development are outcomes of a delicate interplay between genetic and environmental factors. Nutrition emerges as a pivotal environmental determinant, orchestrating proper organogenesis. Malnutrition disrupts normal embryo development and potentially leads to chronic diseases in later life. Our understanding of the specific metabolic routes and their impact on kidney development is still elusive. Here, we used a multi-omics approach to study the importance of glucose metabolism to proper kidney development. We cultured E13.5 embryonic kidneys in the presence or absence of partial inhibition of glycolysis and submitted it to transcriptomic and proteomic profiling. We found that glycolysis-derived acetyl-CoA is an intracellular pleiotropic agent pivotal for proper kidney development. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:03:28.250.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD045445 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Jennifer Klein |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-09-18 04:00:51 | ID requested | |
1 | 2023-09-18 13:50:43 | announced | |
⏵ 2 | 2024-10-22 06:03:28 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: Metabolism, Diet, glycolysis |
mitochondria,kidney |
Nephron progenitor cells, Proteomics |
Contact List
Giovane G Tortelote |
contact affiliation | Assistant Professor of Pediatrics Tulane University School of Medicine New Orleans, LA United States |
contact email | gtortelote@tulane.edu |
lab head | |
Jennifer Klein |
contact affiliation | LSUHSC |
contact email | jklei1@lsuhsc.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/09/PXD045445 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD045445
- Label: PRIDE project
- Name: Metabolic Roadmap to Nephrogenesis