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PXD045376

PXD045376 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMulti-omics Analyses Reveal Mitochondrial Dysfunction Con-tributing to Temozolomide Resistance in Glioblastoma Cells
DescriptionGlioblastoma (GBM) is the most common and aggressive malignant brain tumor with poor prognosis. Temozolomide (TMZ) is the standard chemotherapy for glioblastoma treatment, but TMZ resistance significantly compromises its efficacy. In the present study, we generated a TMZ-resistant cell line and identified that mitochondrial dysfunction was a novel factor contrib-uting to TMZ resistance though multi-omics analyses and energy metabolism analysis. Further-more, we found that rotenone treatment induced TMZ resistance to a certain level in glioblastoma cells. Notably, we further demonstrated that elevated Ca2+ levels and JNK–STAT3 pathway activa-tion contributed to TMZ resistance and that inhibiting JNK or STAT3 increases susceptibility to TMZ. Taken together, our results indicate that co-administering TMZ with a JNK or STAT3 inhibi-tor holds promise as a potentially effective treatment for glioblastoma.
HostingRepositoryiProX
AnnounceDate2023-09-13
AnnouncementXMLSubmission_2023-10-07_23:58:55.187.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHuaijin Zhang
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListTMT6plex reporter fragment; iodoacetamide derivatized residue
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-09-13 20:51:37ID requested
12023-09-21 19:24:23announced
22023-10-07 23:59:27announced2023-10-08: Update information
Publication List
Zhang H, Chen Y, Liu X, Deng H, Multi-Omics Analyses Reveal Mitochondrial Dysfunction Contributing to Temozolomide Resistance in Glioblastoma Cells. Biomolecules, 13(9):(2023) [pubmed]
Keyword List
submitter keyword: glioblastoma, temozolomide, chemoresistance, mitochondrial dysfunction, mitochondrial retrograde signaling
Contact List
Haiteng Deng
contact affiliationTsinghua University
contact emaildht@mail.tsinghua.edu.cn
lab head
Huaijin Zhang
contact affiliationTsinghua University
contact emailzhang-hj16@mails.tsinghua.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI