PXD045376
PXD045376 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Multi-omics Analyses Reveal Mitochondrial Dysfunction Con-tributing to Temozolomide Resistance in Glioblastoma Cells |
Description | Glioblastoma (GBM) is the most common and aggressive malignant brain tumor with poor prognosis. Temozolomide (TMZ) is the standard chemotherapy for glioblastoma treatment, but TMZ resistance significantly compromises its efficacy. In the present study, we generated a TMZ-resistant cell line and identified that mitochondrial dysfunction was a novel factor contrib-uting to TMZ resistance though multi-omics analyses and energy metabolism analysis. Further-more, we found that rotenone treatment induced TMZ resistance to a certain level in glioblastoma cells. Notably, we further demonstrated that elevated Ca2+ levels and JNK–STAT3 pathway activa-tion contributed to TMZ resistance and that inhibiting JNK or STAT3 increases susceptibility to TMZ. Taken together, our results indicate that co-administering TMZ with a JNK or STAT3 inhibi-tor holds promise as a potentially effective treatment for glioblastoma. |
HostingRepository | iProX |
AnnounceDate | 2023-09-13 |
AnnouncementXML | Submission_2023-10-07_23:58:55.187.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Huaijin Zhang |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | TMT6plex reporter fragment; iodoacetamide derivatized residue |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-09-13 20:51:37 | ID requested | |
1 | 2023-09-21 19:24:23 | announced | |
⏵ 2 | 2023-10-07 23:59:27 | announced | 2023-10-08: Update information |
Publication List
Zhang H, Chen Y, Liu X, Deng H, Multi-Omics Analyses Reveal Mitochondrial Dysfunction Contributing to Temozolomide Resistance in Glioblastoma Cells. Biomolecules, 13(9):(2023) [pubmed] |
Keyword List
submitter keyword: glioblastoma, temozolomide, chemoresistance, mitochondrial dysfunction, mitochondrial retrograde signaling |
Contact List
Haiteng Deng | |
---|---|
contact affiliation | Tsinghua University |
contact email | dht@mail.tsinghua.edu.cn |
lab head | |
Huaijin Zhang | |
contact affiliation | Tsinghua University |
contact email | zhang-hj16@mails.tsinghua.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |