PXD045376

PXD045376 is an original dataset announced via ProteomeXchange.

Title	Multi-omics Analyses Reveal Mitochondrial Dysfunction Con-tributing to Temozolomide Resistance in Glioblastoma Cells
Description	Glioblastoma (GBM) is the most common and aggressive malignant brain tumor with poor prognosis. Temozolomide (TMZ) is the standard chemotherapy for glioblastoma treatment, but TMZ resistance significantly compromises its efficacy. In the present study, we generated a TMZ-resistant cell line and identified that mitochondrial dysfunction was a novel factor contrib-uting to TMZ resistance though multi-omics analyses and energy metabolism analysis. Further-more, we found that rotenone treatment induced TMZ resistance to a certain level in glioblastoma cells. Notably, we further demonstrated that elevated Ca2+ levels and JNK–STAT3 pathway activa-tion contributed to TMZ resistance and that inhibiting JNK or STAT3 increases susceptibility to TMZ. Taken together, our results indicate that co-administering TMZ with a JNK or STAT3 inhibi-tor holds promise as a potentially effective treatment for glioblastoma.
HostingRepository	iProX
AnnounceDate	2023-09-13
AnnouncementXML	Submission_2023-10-07_23:58:55.187.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Huaijin Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	TMT6plex reporter fragment; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-13 20:51:37	ID requested
1	2023-09-21 19:24:23	announced
⏵ 2	2023-10-07 23:59:27	announced	2023-10-08: Update information

Zhang H, Chen Y, Liu X, Deng H, Multi-Omics Analyses Reveal Mitochondrial Dysfunction Contributing to Temozolomide Resistance in Glioblastoma Cells. Biomolecules, 13(9):(2023) [pubmed]

submitter keyword: glioblastoma, temozolomide, chemoresistance, mitochondrial dysfunction, mitochondrial retrograde signaling

Haiteng Deng
contact affiliation	Tsinghua University
contact email	dht@mail.tsinghua.edu.cn
lab head
Huaijin Zhang
contact affiliation	Tsinghua University
contact email	zhang-hj16@mails.tsinghua.edu.cn
dataset submitter

iProX dataset URI