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PXD045357

PXD045357 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleWhole cell proteome of OCI-AML3 FKBP12(F36V) cells with dTAG-13 treatment
DescriptionThe nucleolar scaffold protein NPM1 acts as a multifunctional regulator of cellular homeostasis, genome integrity, and stress response. NPM1 mutations, known as NPM1c variants that promote its aberrant cytoplasmic localization, are the most frequent genetic alterations in acute myeloid leukemia (AML). A hallmark of AML cells is their dependency on elevated autophagic flux. In order to identify the proteome changes upon NPM1 and NPM1c overexpression, we performed TMT-labeled mass spectrometry analysis of whole cell lysates.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:13:27.384.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterStefan Müller
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Exploris 240
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-09-13 09:28:51ID requested
12023-10-28 09:50:07announced
22024-10-22 06:13:27announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: OCI-AML3 dTAG NPM1c proteome
Contact List
Stefan Müller
contact affiliationlab head and vice director of the Insitute of Biochemistry 2 (Frankfurt)
contact emailste.mueller@em.uni-frankfurt.de
lab head
Stefan Müller
contact affiliationInstitute of Biochemistry II University Hospital Building 75 Theodor-Stern-Kai 7 60590 Frankfurt (Main)
contact emailag-mueller@gmx.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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