PXD045357 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Whole cell proteome of OCI-AML3 FKBP12(F36V) cells with dTAG-13 treatment |
Description | The nucleolar scaffold protein NPM1 acts as a multifunctional regulator of cellular homeostasis, genome integrity, and stress response. NPM1 mutations, known as NPM1c variants that promote its aberrant cytoplasmic localization, are the most frequent genetic alterations in acute myeloid leukemia (AML). A hallmark of AML cells is their dependency on elevated autophagic flux. In order to identify the proteome changes upon NPM1 and NPM1c overexpression, we performed TMT-labeled mass spectrometry analysis of whole cell lysates. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:13:27.384.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Stefan Müller |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Exploris 240 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-09-13 09:28:51 | ID requested | |
1 | 2023-10-28 09:50:07 | announced | |
⏵ 2 | 2024-10-22 06:13:27 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: OCI-AML3 dTAG NPM1c proteome |
Contact List
Stefan Müller |
contact affiliation | lab head and vice director of the Insitute of Biochemistry 2 (Frankfurt) |
contact email | ste.mueller@em.uni-frankfurt.de |
lab head | |
Stefan Müller |
contact affiliation | Institute of Biochemistry II University Hospital Building 75 Theodor-Stern-Kai 7 60590 Frankfurt (Main) |
contact email | ag-mueller@gmx.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD045357 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD045357
- Label: PRIDE project
- Name: Whole cell proteome of OCI-AML3 FKBP12(F36V) cells with dTAG-13 treatment