PXD045355

PXD045355 is an original dataset announced via ProteomeXchange.

Title	Identification of ciliary protein interactome during senescence
Description	Despite the importance of cellular senescence in human health, how damaged cells undergo senescence remains vague. We have previously shown that the translocation of a ciliary protein FBF1 to nucleus is essential for senescence induction in stressed cells. However, how dose FBF1 translocate from ciliary base to the nucleus still unclear. We employed BioID analysis to identify the potential interactor of FBF1 and associated protein that regulate FBF1 translocation. We discovered the ciliary base protein, CENEXIN1(ODF2), as interactor by using FBF1 as prey. We also explored CENEXIN1 (ODF2)interactome by APEX2-based BioID to idenfity KIFC3, a minus-end-directed kinesin, as downstream player that regulate the ciliary protein translocation.
HostingRepository	PRIDE
AnnounceDate	2024-08-19
AnnouncementXML	Submission_2024-08-19_13:10:46.518.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD045355
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jielu Robichaud
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	biotinylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-13 07:54:42	ID requested
⏵ 1	2024-08-19 13:10:46	announced

10.6019/PXD045355;

submitter keyword: primary cilia, senescence

Jinghua Hu
contact affiliation	Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
contact email	Hu.Jinghua@mayo.edu
lab head
Jielu Robichaud
contact affiliation	Mayo Clinic
contact email	hao.jielu@mayo.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD045355
     1. Label: PRIDE project
     2. Name: Identification of ciliary protein interactome during senescence