PXD045280

PXD045280 is an original dataset announced via ProteomeXchange.

Title	Proteomic characteristics of plasma from calves with diarrhea before and after drug intervention
Description	Dampness heat diarrhea (DHD) is the most common type of diarrhea in calves according to the Traditional Chinese veterinary medicine (TCVM) and its complex etiology bring great challenges to the treatment of this disease. Huangbai jianpi decoction (HBJP) is efficacy to treat DHD in calves. The therapeutic mechanism of HBJP is urgently required to be applied this decoction to the precise treatment of this syndrome in the clinic. We herein aimed to explore the mechanism of HBJP in DHD by using multi-omic analysis from DHD calves in Northwest China region. Proteomic results showed that some protein, including coagulation factor XIII B chain precursor (F13 B), alpha-1-acid glycoprotein precursor (ORM1) and polymeric immunoglobulin receptor (PIGR), had significant changes after treatment with HBJP. Metabolomics data demonstrated that the plasma of DHD calves were associated with high abundance of choline and pirbuterol, while after treated by HBJP the plasma was abundant in glycocholic acid and taurocholic acid. Bacterial gene sequence analysis showed that the feces of DHD calves had the highest abundance of Escherichia-Shigella, while after treated by HBJP the feces were more enriched in Megasphaera, Prevotella_2 and Bifidobacterium. Our study demonstrated that plasma proteins and metabolites, and gut microbiota were significantly different between before and after treated by HBJP in calves, and provided the theoretical basis for elucidating the mechanism of HBJP in the treatment of DHD.
HostingRepository	iProX
AnnounceDate	2023-09-11
AnnouncementXML	Submission_2023-09-20_00:53:11.336.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zunxiang Yan
SpeciesList	scientific name: Bos taurus; NCBI TaxID: 9913;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-11 20:28:32	ID requested
⏵ 1	2023-09-20 00:53:11	announced

Dataset with its publication pending

submitter keyword: Proteomic, plasma, calves, diarrhea, drug, intervention

Jianxi Li
contact affiliation	Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS
contact email	lzjianxil@163.com
lab head
Zunxiang Yan
contact affiliation	Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS
contact email	743318367@qq.com
dataset submitter

iProX dataset URI