PXD045276

PXD045276 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic Analysis Reveals Trilaciclib-Induced Senescence
Description	Trilaciclib, a CDK4/6 inhibitor, was approved as a myeloprotective agent for extensive-stage small cell lung cancer in 2021. It achieves this by inducing a temporary cell cycle arrest in bone marrow cells. While it has been studied in various cancer types, its potential in haematological cancers remains unexplored. This research aimed to investigate the efficacy of trilaciclib in haematological cancers.
HostingRepository	PRIDE
AnnounceDate	2024-06-16
AnnouncementXML	Submission_2024-06-15_23:58:07.660.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Matthias Trost
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	carbamoylated residue
Instrument	Q Exactive HF; Bruker Daltonics timsTOF series

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-11 12:34:59	ID requested
⏵ 1	2024-06-15 23:58:08	announced

Publication List

Hermosilla-Trespaderne M, Hu-Yang MX, Dannoura A, Frey AM, George AL, Trost M, Mar, í, n-Rubio JL, Proteomic Analysis Reveals Trilaciclib-Induced Senescence. Mol Cell Proteomics, 23(6):100778(2024) [pubmed]
10.1016/j.mcpro.2024.100778;

Hermosilla-Trespaderne M, Hu-Yang MX, Dannoura A, Frey AM, George AL, Trost M, Mar, í, n-Rubio JL, Proteomic Analysis Reveals Trilaciclib-Induced Senescence. Mol Cell Proteomics, 23(6):100778(2024) [pubmed]

10.1016/j.mcpro.2024.100778;

Keyword List

submitter keyword: proteomics, resistance, trilaciclib, leukaemia, senescence

submitter keyword: proteomics, resistance, trilaciclib, leukaemia, senescence

Contact List

Matthias Trost
contact affiliation	Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
contact email	matthias.trost@newcastle.ac.uk
lab head
Matthias Trost
contact affiliation	Newcastle University
contact email	matthias.trost@ncl.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD045276
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD045276

PRIDE project URI

Repository Record List

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