PXD045197

PXD045197 is an original dataset announced via ProteomeXchange.

Title	Dynamics of Mitochondrial Proteome and Acetylome in Glioblastoma Cells with Contrasting Metabolic Phenotypes
Description	The dysregulated energy metabolism of glioblastoma cells is a critical factor in tumor development and progression. Lysine acetylation, regulated by the mitochondrial enzyme SIRT3, is known to play a key role in the metabolic phenotype of glioblastoma. To better understand how SIRT3 regulates mitochondrial metabolism, we inhibited SIRT3 and examined the proteome and acetylome of two glioblastoma cell lines with different metabolic preferences. Our results indicate that protein synthesis machineries are regulated by lysine acetylation and play a role in the metabolic phenotype. We also identified new SIRT3 targets that have not been previously associated with specific functions, highlighting their potential as future targets for further study. These findings enhance our understanding of the complex regulation of energy metabolism in glioblastoma and provide potential targets for future therapies.
HostingRepository	PRIDE
AnnounceDate	2024-05-23
AnnouncementXML	Submission_2024-05-23_00:07:19.615.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Diana Lashidua Fernandez Coto
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-07 11:58:41	ID requested
⏵ 1	2024-05-23 00:07:20	announced

Fern, á, ndez-Coto DL, Gil J, Ayala G, Encarnaci, ó, n-Guevara S, Dynamics of Mitochondrial Proteome and Acetylome in Glioblastoma Cells with Contrasting Metabolic Phenotypes. Int J Mol Sci, 25(6):(2024) [pubmed]

10.3390/ijms25063450;

submitter keyword: metabolism, lysine acetylation, SIRT3,Glioblastoma, mitochondria

Sergio Manuel Encarnacion Guevara
contact affiliation	Programa de Genomica Funcional de procariontes, Centro de Ciencias Genomicas-UNAM. Avenida Universidad s/n, Colonia Chamilpa, Cuernavaca, Morelos, CP 62210, México.
contact email	encarnac@ccg.unam.mx
lab head
Diana Lashidua Fernandez Coto
contact affiliation	Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México
contact email	cocodi_trent@hotmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD045197

PRIDE project URI

• PRIDE
  1. PXD045197
     1. Label: PRIDE project
     2. Name: Dynamics of Mitochondrial Proteome and Acetylome in Glioblastoma Cells with Contrasting Metabolic Phenotypes